TB-Profiler result

Run: ERR11083153
Summary

Run ID: ERR11083153

Sample name:

Date: 11-04-2023 23:36:34

Number of reads: 3724076

Percentage reads mapped: 99.74

Strain: lineage4.6.3

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.6 Euro-American T;LAM None 1.0
lineage4.6.3 Euro-American T;LAM None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8049 p.Ser250Ala missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.2
ccsA 620072 p.Pro61Leu missense_variant 1.0
rpoC 763353 c.-16delG upstream_gene_variant 1.0
rpoC 765658 c.2289C>T synonymous_variant 0.99
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776987 c.1493delC frameshift_variant 1.0
mmpS5 778673 p.Pro78Leu missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 0.99
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
inhA 1674672 c.471C>T synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170065 p.Ala183Gly missense_variant 0.22
Rv1979c 2223293 c.-129A>G upstream_gene_variant 0.99
pepQ 2860159 p.Ala87Gly missense_variant 0.19
fbiD 3339734 p.Ala206Gly missense_variant 0.58
fbiD 3339746 p.Ala210Gly missense_variant 0.26
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
rpoA 3878637 c.-130G>C upstream_gene_variant 0.22
rpoA 3878641 c.-134C>G upstream_gene_variant 0.43
embC 4240409 p.Pro183Ala missense_variant 0.25
embC 4241024 p.Val388Ile missense_variant 1.0
embC 4242185 p.Asp775Asn missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244647 p.Arg472Leu missense_variant 1.0
embB 4246529 p.Ser6Arg missense_variant 0.36
embB 4246584 p.Arg24Pro missense_variant 0.22
embB 4248324 p.Ala604Gly missense_variant 0.21
aftB 4268573 p.Met88Ile missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0