TB-Profiler result

Run: ERR11466038
Summary

Run ID: ERR11466038

Sample name:

Date: 10-01-2024 07:15:37

Number of reads: 4149880

Percentage reads mapped: 99.74

Strain: lineage4.9.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 0.99
lineage4.9.1 Euro-American (H37Rv-like) T1 None 0.92
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 0.98
gyrA 8978 c.1677C>T synonymous_variant 0.96
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781609 p.Ser17Asn missense_variant 0.94
rplC 801077 p.Asp90Gly missense_variant 0.93
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 0.85
katG 2153970 p.Asp714Glu missense_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 0.98
pncA 2289138 p.Leu35Arg missense_variant 0.95
fbiD 3339385 p.Asp90Asn missense_variant 0.87
embA 4242643 c.-590C>T upstream_gene_variant 0.2
embB 4246544 p.Thr11Pro missense_variant 0.3
embB 4246567 c.54G>T synonymous_variant 0.28
whiB6 4338595 c.-75delG upstream_gene_variant 0.95