TB-Profiler result

Run: ERR234139
Summary

Run ID: ERR234139

Sample name:

Date: 31-03-2023 18:00:25

Number of reads: 2168343

Percentage reads mapped: 99.39

Strain: lineage2.2.1

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491027 p.Asn82Thr missense_variant 0.17
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575819 p.Ser158Ala missense_variant 0.27
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620407 p.Pro173Ala missense_variant 0.57
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoB 759620 c.-187A>C upstream_gene_variant 0.23
rpoC 762836 c.-534C>G upstream_gene_variant 0.4
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 767085 p.Asn1239Thr missense_variant 0.27
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303016 p.Val29Gly missense_variant 0.19
Rv1258c 1406253 p.Gly363Val missense_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
embR 1417233 c.115C>T synonymous_variant 0.18
atpE 1461083 c.39T>G synonymous_variant 0.54
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1473747 n.92delA non_coding_transcript_exon_variant 1.0
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.16
fabG1 1673449 p.Thr4Pro missense_variant 0.29
inhA 1674210 c.9A>C synonymous_variant 1.0
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155375 p.Val246Gly missense_variant 0.4
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2169320 p.Leu431Phe missense_variant 0.26
PPE35 2169866 c.747G>C synonymous_variant 0.55
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2288881 p.Arg121Trp missense_variant 1.0
eis 2714355 c.978C>G synonymous_variant 0.56
eis 2714948 p.Phe129Val missense_variant 0.27
ahpC 2725954 c.-239C>T upstream_gene_variant 0.4
pepQ 2859381 c.1038C>G synonymous_variant 0.43
Rv2752c 3064552 p.Arg547Pro missense_variant 0.21
Rv2752c 3064741 p.Gly484Ala missense_variant 0.2
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3449058 p.Ser185Arg missense_variant 0.22
fprA 3473901 c.-106G>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
clpC1 4038857 c.1848C>A synonymous_variant 0.2
clpC1 4039363 p.Ala448Pro missense_variant 0.3
clpC1 4039932 p.Gly258Val missense_variant 0.67
panD 4044207 c.75G>C synonymous_variant 0.33
embC 4241056 c.1194C>G synonymous_variant 0.25
embC 4242476 p.Pro872Ala missense_variant 0.29
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embA 4244375 c.1143C>G synonymous_variant 0.55
aftB 4267647 p.Asp397Gly missense_variant 1.0
aftB 4268812 p.Ser9Ala missense_variant 0.22
ubiA 4269446 p.Val130Ile missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0