TB-Profiler result

Run: ERR245791
Summary

Run ID: ERR245791

Sample name:

Date: 31-03-2023 18:21:33

Number of reads: 11130361

Percentage reads mapped: 99.29

Strain: lineage4.1.2

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7323 p.Pro8Ala missense_variant 0.99
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7493 c.192C>T synonymous_variant 0.19
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8445 p.Arg382Gly missense_variant 0.46
gyrA 9304 p.Gly668Asp missense_variant 0.99
fgd1 491591 p.Lys270Met missense_variant 1.0
rpoB 759831 p.Thr9Pro missense_variant 0.24
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoC 762836 c.-534C>G upstream_gene_variant 0.33
rpoC 765150 p.Gly594Glu missense_variant 1.0
rpoC 767305 p.Tyr1312* stop_gained 0.21
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776659 p.Asp608Asn missense_variant 1.0
mmpL5 777399 p.Thr361Arg missense_variant 0.16
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1417501 c.-154A>C upstream_gene_variant 0.25
rrs 1471659 n.-187C>T upstream_gene_variant 0.99
rrl 1474380 n.723G>T non_coding_transcript_exon_variant 0.21
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.16
fabG1 1673449 p.Thr4Pro missense_variant 0.39
inhA 1674892 p.Asn231Asp missense_variant 0.4
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918069 p.Thr44Pro missense_variant 0.47
PPE35 2168501 p.Phe704Leu missense_variant 1.0
PPE35 2169320 p.Leu431Phe missense_variant 0.15
PPE35 2169866 c.747G>C synonymous_variant 0.41
PPE35 2170156 p.Ala153Pro missense_variant 0.48
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.27
eis 2715586 c.-254G>C upstream_gene_variant 0.67
ahpC 2725954 c.-239C>T upstream_gene_variant 0.22
Rv2752c 3064741 p.Gly484Ala missense_variant 0.29
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3449058 p.Ser185Arg missense_variant 0.32
Rv3083 3449673 p.Tyr390* stop_gained 0.27
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiB 3641955 p.Gly141Arg missense_variant 0.18
ddn 3987013 p.Gly57Ala missense_variant 0.25
clpC1 4038857 c.1848C>A synonymous_variant 0.25
clpC1 4039363 p.Ala448Pro missense_variant 0.33
clpC1 4039932 p.Gly258Val missense_variant 0.34
embC 4241429 p.Phe523Val missense_variant 0.53
embC 4241456 p.Ala532Pro missense_variant 0.48
embC 4242476 p.Pro872Ala missense_variant 0.33
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embC 4242822 p.Val987Gly missense_variant 0.23
embB 4247121 p.Ser203Leu missense_variant 1.0
ubiA 4269529 p.Ala102Gly missense_variant 0.16
ethA 4327672 c.-199G>A upstream_gene_variant 0.18
whiB6 4338595 c.-75delG upstream_gene_variant 1.0