TB-Profiler result

Run: ERR2515908

Summary

Run ID: ERR2515908

Sample name:

Date: 31-03-2023 21:11:08

Number of reads: 449515

Percentage reads mapped: 99.63

Strain: lineage4.3.2.1

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 1.0
lineage4.3.2 Euro-American (LAM) LAM3 None 1.0
lineage4.3.2.1 Euro-American (LAM) LAM3 RD761 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5520 p.Pro94Leu missense_variant 1.0
gyrA 7222 c.-80C>T upstream_gene_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 576439 c.1092G>A synonymous_variant 0.11
rpoC 764995 c.1626C>G synonymous_variant 1.0
rpoC 765976 c.2608delT frameshift_variant 0.11
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472337 n.492C>T non_coding_transcript_exon_variant 1.0
inhA 1674589 p.Met130Leu missense_variant 0.1
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170535 c.78G>C synonymous_variant 0.17
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289702 c.-461T>C upstream_gene_variant 0.11
kasA 2518756 c.642G>A synonymous_variant 0.13
Rv2752c 3067129 c.-938G>A upstream_gene_variant 0.13
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiA 3641285 p.Gly248Asp missense_variant 0.2
clpC1 4038167 c.2538C>T synonymous_variant 0.11
clpC1 4038287 c.2418C>T synonymous_variant 1.0
embC 4241971 c.2109T>C synonymous_variant 0.11
embA 4242643 c.-590C>T upstream_gene_variant 1.0
aftB 4267782 c.1054delG frameshift_variant 0.12
aftB 4268352 p.Leu162Pro missense_variant 0.11
aftB 4268813 c.24G>T synonymous_variant 0.1
ubiA 4269661 p.Ala58Val missense_variant 0.12
aftB 4269729 c.-893G>C upstream_gene_variant 0.13
ubiA 4269916 c.-83G>A upstream_gene_variant 0.11
ethA 4327923 c.-450C>T upstream_gene_variant 0.1
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0