TB-Profiler result

Run: ERR2516334
Summary

Run ID: ERR2516334

Sample name:

Date: 19-10-2023 23:35:35

Number of reads: 11488417

Percentage reads mapped: 99.66

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 0.75
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 7117 p.Met626Ile missense_variant 0.74
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 0.36
gyrA 9304 p.Gly668Asp missense_variant 0.28
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 778735 c.-255G>A upstream_gene_variant 0.77
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.81
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154915 c.1197A>G synonymous_variant 0.26
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518205 p.Ser31Arg missense_variant 0.68
ald 3086767 c.-53A>C upstream_gene_variant 0.77
ald 3086788 c.-32T>C upstream_gene_variant 0.19
fbiD 3338935 c.-183T>C upstream_gene_variant 0.8
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.22
Rv3236c 3612118 c.999G>A synonymous_variant 0.8
embC 4242161 p.Ala767Thr missense_variant 0.72
embA 4242643 c.-590C>T upstream_gene_variant 0.99
embA 4244000 c.768G>A synonymous_variant 0.72
whiB6 4338250 p.Ala91Val missense_variant 0.75
whiB6 4338595 c.-75delG upstream_gene_variant 1.0