TB-Profiler result

Run: ERR2706940
Summary

Run ID: ERR2706940

Sample name:

Date: 31-03-2023 23:10:39

Number of reads: 5298206

Percentage reads mapped: 99.73

Strain: lineage4.9

Drug-resistance: MDR-TB

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761277 p.Ile491Phe missense_variant 1.0 rifampicin
rrs 1472362 n.517C>T non_coding_transcript_exon_variant 1.0 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
embB 4247730 p.Gly406Ala missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 6379 c.-923C>A upstream_gene_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 0.99
mshA 576108 p.Ala254Gly missense_variant 0.17
rplC 801355 p.His183Tyr missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154322 p.Tyr597Ser missense_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.99
PPE35 2170036 p.Val193Met missense_variant 1.0
rpoA 3878567 c.-60C>G upstream_gene_variant 0.4
embB 4246584 p.Arg24Pro missense_variant 0.15
whiB6 4338595 c.-75delG upstream_gene_variant 1.0