Run ID: ERR2706941
Sample name:
Date: 19-10-2023 12:12:13
Number of reads: 3745408
Percentage reads mapped: 99.59
Strain: lineage4
Drug-resistance: RR-TB
| Drug | Resistance | Supporting mutations |
|---|---|---|
| Rifampicin | R | rpoB p.His445Thr (0.99) |
| Isoniazid | ||
| Ethambutol | R | embB p.Asp328Tyr (1.00) |
| Pyrazinamide | R | pncA p.Ala146Thr (1.00) |
| Streptomycin | R | rpsL p.Lys43Arg (1.00) |
| Fluoroquinolones | ||
| Moxifloxacin | ||
| Ofloxacin | ||
| Levofloxacin | ||
| Ciprofloxacin | ||
| Aminoglycosides | ||
| Amikacin | ||
| Capreomycin | ||
| Kanamycin | ||
| Cycloserine | ||
| Ethionamide | R | ethA c.253dupG (1.00) |
| Clofazimine | ||
| Para-aminosalicylic_acid | ||
| Delamanid | ||
| Bedaquiline | ||
| Linezolid |
| Lineage | Family | Main Spoligotype | RDs | Frequency |
|---|---|---|---|---|
| lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
|---|---|---|---|---|---|
| rpoB | 761139 | p.His445Thr | missense_variant | 0.99 | rifampicin |
| rpsL | 781687 | p.Lys43Arg | missense_variant | 1.0 | streptomycin |
| pncA | 2288806 | p.Ala146Thr | missense_variant | 1.0 | pyrazinamide |
| embB | 4247495 | p.Asp328Tyr | missense_variant | 1.0 | ethambutol |
| ethA | 4327220 | c.253dupG | frameshift_variant | 1.0 | ethionamide |
| Gene | Chromosome position | Mutation | Type | Estimated fraction |
|---|---|---|---|---|
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
| rplC | 800977 | p.Ile57Val | missense_variant | 1.0 |
| fbiC | 1305457 | p.Pro843Ala | missense_variant | 1.0 |
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
| katG | 2154980 | c.1132C>T | synonymous_variant | 1.0 |
| katG | 2155178 | p.Ala312Pro | missense_variant | 1.0 |
| PPE35 | 2170811 | c.-199C>T | upstream_gene_variant | 1.0 |
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 |
| kasA | 2518265 | p.Val51Ile | missense_variant | 0.99 |
| eis | 2715223 | p.Arg37Gln | missense_variant | 1.0 |
| Rv3083 | 3449145 | c.642G>A | synonymous_variant | 1.0 |
| embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
| aftB | 4268076 | p.Met254Ala | missense_variant | 1.0 |
| ubiA | 4269121 | p.Phe238Ser | missense_variant | 0.97 |
| ubiA | 4269188 | p.Thr216Ala | missense_variant | 0.95 |
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
