TB-Profiler result

Run: ERR2707226
Summary

Run ID: ERR2707226

Sample name:

Date: 19-10-2023 12:04:26

Number of reads: 5105834

Percentage reads mapped: 99.72

Strain: lineage4.6.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.6 Euro-American T;LAM None 0.93
lineage4.6.1 Euro-American (Uganda) T2 RD724 0.83
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7539 p.Thr80Ala missense_variant 0.92
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8717 c.1416C>T synonymous_variant 0.94
gyrA 8774 c.1473C>A synonymous_variant 0.92
gyrA 9304 p.Gly668Asp missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1417040 p.Leu103Arg missense_variant 0.93
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2221767 p.His466Gln missense_variant 0.94
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3475318 p.Gly438Trp missense_variant 0.96
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338391 p.Thr44Ile missense_variant 0.94
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407555 c.648A>G synonymous_variant 0.89