TB-Profiler result

Run: ERR3273184
Summary

Run ID: ERR3273184

Sample name:

Date: 01-04-2023 01:15:12

Number of reads: 2230196

Percentage reads mapped: 99.63

Strain: lineage4.9

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Trp missense_variant 1.0 rifampicin
rrs 1472359 n.514A>C non_coding_transcript_exon_variant 1.0 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2288848 c.393dupC frameshift_variant 1.0 pyrazinamide, pyrazinamide
embB 4247574 p.Asp354Ala missense_variant 0.96 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5174 c.-66G>T upstream_gene_variant 0.99
gyrB 5450 p.Glu71Gln missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
fgd1 491433 c.651C>T synonymous_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv2752c 3066104 p.Asn30Asp missense_variant 0.99
embA 4243204 c.-28delT upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0