TB-Profiler result

Run: ERR4407543
Summary

Run ID: ERR4407543

Sample name:

Date: 01-04-2023 05:49:21

Number of reads: 417326

Percentage reads mapped: 99.23

Strain: lineage2.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491027 p.Asn82Thr missense_variant 0.44
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
mshA 576750 p.Lys468Thr missense_variant 0.2
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoB 759615 c.-192A>C upstream_gene_variant 0.25
rpoB 760638 c.834_835delCG frameshift_variant 0.15
rpoB 761876 c.2070C>A synonymous_variant 0.13
rpoB 762256 p.Ala817Val missense_variant 0.14
rpoB 762483 c.2678delT frameshift_variant 0.12
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 766767 p.His1133Arg missense_variant 0.13
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpL5 778954 c.-474T>C upstream_gene_variant 0.13
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303016 p.Val29Gly missense_variant 0.27
fbiC 1304031 c.1101C>A synonymous_variant 0.13
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
Rv1258c 1407059 p.Trp94Cys missense_variant 0.14
embR 1417176 p.Ala58Ser missense_variant 0.11
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1473169 n.1324A>T non_coding_transcript_exon_variant 0.25
rrl 1475461 n.1804A>G non_coding_transcript_exon_variant 0.11
rrl 1476078 n.2421C>T non_coding_transcript_exon_variant 0.2
fabG1 1673542 p.Leu35Met missense_variant 0.18
inhA 1674138 c.-64C>A upstream_gene_variant 0.12
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223093 c.72C>T synonymous_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289406 c.-165G>T upstream_gene_variant 0.14
folC 2746660 c.938delT frameshift_variant 0.11
pepQ 2860342 p.Asp26Gly missense_variant 0.12
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448554 p.Ile17Met missense_variant 0.17
Rv3083 3448620 p.Glu39Asp missense_variant 0.12
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3475077 c.1071C>T synonymous_variant 0.11
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
fbiB 3642667 p.Gly378Val missense_variant 0.18
alr 3841396 p.Gly9Arg missense_variant 0.25
clpC1 4039484 c.1221T>G synonymous_variant 0.33
clpC1 4039960 p.Thr249Ala missense_variant 0.11
embC 4240446 p.Pro195Gln missense_variant 0.12
embC 4240520 p.Thr220Ala missense_variant 0.13
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4242724 c.-509G>A upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embB 4248091 c.1579delT frameshift_variant 0.14
aftB 4267647 p.Asp397Gly missense_variant 1.0
aftB 4268643 p.Tyr65Phe missense_variant 0.2
ethR 4327868 p.Ile107Asn missense_variant 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0