TB-Profiler result

Run: ERR4553985

Summary

Run ID: ERR4553985

Sample name:

Date: 01-04-2023 06:27:37

Number of reads: 946459

Percentage reads mapped: 99.73

Strain: lineage4.9

Drug-resistance: MDR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761139 p.His445Asp missense_variant 1.0 rifampicin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6166 c.927C>T synonymous_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.47
embR 1417186 c.162C>G synonymous_variant 0.11
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1476102 n.2445C>T non_coding_transcript_exon_variant 0.17
tlyA 1917972 c.33A>G synonymous_variant 0.96
ndh 2102938 c.105G>A synonymous_variant 0.12
Rv1979c 2221892 p.Ser425Pro missense_variant 0.1
pncA 2289070 p.Phe58Val missense_variant 1.0
rpoA 3878072 p.Tyr146His missense_variant 0.11
embC 4240413 p.Leu184Gln missense_variant 0.14
embB 4246584 p.Arg24Pro missense_variant 0.4
embB 4248319 c.1806A>C synonymous_variant 0.15
aftB 4269171 c.-335C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408063 p.Arg47Gln missense_variant 1.0