TB-Profiler result

Run: ERR4811592

Summary

Run ID: ERR4811592

Sample name:

Date: 20-10-2023 00:51:07

Number of reads: 7258364

Percentage reads mapped: 99.11

Strain: lineage4.4.2

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.4 Euro-American S;T None 0.93
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.05
lineage4.4.2 Euro-American T1;T2 None 0.93
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoC 766363 c.2994G>A synonymous_variant 0.94
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.11
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1416550 c.798C>T synonymous_variant 0.93
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
Rv2752c 3066099 p.Met31Ile missense_variant 0.93
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448348 c.-156G>A upstream_gene_variant 0.93
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiB 3641777 c.243G>A synonymous_variant 0.11
rpoA 3878641 c.-135delG upstream_gene_variant 0.1
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4245680 p.Lys816Asn missense_variant 0.94
embB 4246508 c.-6G>A upstream_gene_variant 0.93
aftB 4268928 c.-92C>T upstream_gene_variant 0.93
aftB 4269375 c.-539G>A upstream_gene_variant 0.95
whiB6 4338595 c.-75delG upstream_gene_variant 1.0