TB-Profiler result

Run: ERR4815430
Summary

Run ID: ERR4815430

Sample name:

Date: 01-04-2023 13:51:33

Number of reads: 757396

Percentage reads mapped: 99.71

Strain: lineage4.8

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
ethA 4327102 c.371dupG frameshift_variant 0.11 ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
fgd1 491014 p.Thr78Pro missense_variant 0.26
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rplC 800664 c.-145G>A upstream_gene_variant 0.96
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102897 p.His49Pro missense_variant 0.11
katG 2154948 c.1164G>A synonymous_variant 0.12
PPE35 2169044 c.1569G>C synonymous_variant 1.0
PPE35 2170446 p.Ser56Leu missense_variant 0.14
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ribD 2987588 p.Tyr250* stop_gained 0.13
Rv2752c 3067180 c.-989C>A upstream_gene_variant 1.0
thyA 3074654 c.-183T>G upstream_gene_variant 0.23
clpC1 4038825 p.Ile627Thr missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
ubiA 4269864 c.-31C>G upstream_gene_variant 0.21
ethA 4326013 c.1461G>T synonymous_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0