TB-Profiler result

Run: ERR4816876
Summary

Run ID: ERR4816876

Sample name:

Date: 01-04-2023 14:40:51

Number of reads: 557038

Percentage reads mapped: 91.74

Strain: lineage4.1.1.3.1

Drug-resistance: Pre-XDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.1 Euro-American (X-type) X1;X2;X3 None 1.0
lineage4.1.1.3 Euro-American (X-type) X1;X3 RD193 1.0
lineage4.1.1.3.1 Euro-American (X-type) X1;X3 RD193 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrA 7582 p.Asp94Gly missense_variant 1.0 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
rpoB 761277 p.Ile491Phe missense_variant 1.0 rifampicin
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.6 streptomycin
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol
gid 4408100 c.102delG frameshift_variant 1.0 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoC 764755 c.1386C>T synonymous_variant 0.1
rpoC 765150 p.Gly594Glu missense_variant 1.0
rpoC 765366 p.Thr666Ile missense_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777119 p.His454Gln missense_variant 0.11
mmpL5 777122 c.1359C>T synonymous_variant 0.11
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rplC 800627 c.-182C>T upstream_gene_variant 0.11
rplC 800648 c.-161A>T upstream_gene_variant 0.1
fbiC 1303601 p.Glu224Gly missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.46
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.46
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.5
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.44
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.44
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.47
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.53
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.53
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.6
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.54
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.13
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.64
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.69
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.69
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.28
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.64
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.57
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.57
rrs 1472670 n.825G>T non_coding_transcript_exon_variant 0.5
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.86
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.71
rrs 1472677 n.832C>T non_coding_transcript_exon_variant 0.71
rrs 1472681 n.837_838delTT non_coding_transcript_exon_variant 0.71
rrs 1472687 n.842_843insC non_coding_transcript_exon_variant 0.6
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.62
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.57
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.64
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.64
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.56
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.56
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.4
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.4
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.4
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.25
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.29
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.29
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.33
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.33
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.6
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.4
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.4
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.33
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.25
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.33
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.33
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.33
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.33
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.33
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.67
rrl 1474228 n.571T>C non_coding_transcript_exon_variant 0.67
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.67
rrl 1474252 n.595T>A non_coding_transcript_exon_variant 0.67
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169324 p.Gly430Asp missense_variant 0.12
PPE35 2169490 p.Gly375Arg missense_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2290151 c.-910A>T upstream_gene_variant 0.13
ribD 2987169 p.Gln111Lys missense_variant 0.1
thyA 3073777 p.Leu232Pro missense_variant 0.12
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embA 4244880 c.1650delG frameshift_variant 0.2
embB 4249408 c.2895G>A synonymous_variant 1.0
aftB 4268626 p.Gly71Cys missense_variant 0.2
aftB 4269369 c.-533G>A upstream_gene_variant 0.14
aftB 4269540 c.-704C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0