TB-Profiler result

Run: ERR4818728
Summary

Run ID: ERR4818728

Sample name:

Date: 01-04-2023 15:43:07

Number of reads: 760666

Percentage reads mapped: 99.12

Strain: lineage4.3.4.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 1.0
lineage4.3.4 Euro-American (LAM) LAM RD174 1.0
lineage4.3.4.2 Euro-American (LAM) LAM1;LAM4;LAM11 RD174 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5151 c.-89C>T upstream_gene_variant 0.14
gyrB 6140 p.Val301Leu missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8662 p.Asp454Gly missense_variant 0.12
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoB 759873 p.Asn23His missense_variant 0.11
rpoB 760402 c.599delC frameshift_variant 0.12
rpoB 761152 p.Leu449Gln missense_variant 0.13
rpoB 761370 p.Ile522Phe missense_variant 0.13
rpoB 762360 c.2555delA frameshift_variant 0.1
rpoC 764995 c.1626C>G synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775894 c.2575_2586delAAGGAGGAGATC conservative_inframe_deletion 0.15
mmpL5 776013 p.Trp823Leu missense_variant 0.1
mmpL5 778236 p.Phe82Tyr missense_variant 0.22
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304631 c.1701C>T synonymous_variant 0.13
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
fabG1 1673300 c.-140G>T upstream_gene_variant 0.1
rpsA 1833545 p.Pro2Thr missense_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918627 p.Leu230Val missense_variant 0.12
katG 2154736 p.Lys459Thr missense_variant 0.14
katG 2154781 p.Ala444Val missense_variant 0.12
katG 2155376 p.Val246Phe missense_variant 0.11
PPE35 2169140 c.1473G>T synonymous_variant 0.14
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519093 c.980_982dupGCG disruptive_inframe_insertion 0.14
Rv2752c 3066219 c.-28T>A upstream_gene_variant 0.14
thyA 3073851 c.621C>T synonymous_variant 0.11
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339182 p.Ala22Val missense_variant 0.11
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0
fbiA 3640395 c.-148T>C upstream_gene_variant 1.0
clpC1 4038287 c.2418C>T synonymous_variant 1.0
clpC1 4040258 c.446delA frameshift_variant 0.2
clpC1 4040264 c.441C>A synonymous_variant 0.2
embC 4240463 p.Phe201Leu missense_variant 0.12
embC 4240839 p.Trp326* stop_gained 0.18
embA 4242643 c.-590C>T upstream_gene_variant 0.91
embC 4242746 c.2886_2887delAC frameshift_variant 0.11
embA 4245741 p.Thr837Ala missense_variant 1.0
embB 4247784 p.Arg424Gln missense_variant 0.11
ethA 4328019 c.-546G>A upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0