TB-Profiler result

Run: ERR4820001
Summary

Run ID: ERR4820001

Sample name:

Date: 20-10-2023 09:07:04

Number of reads: 2106898

Percentage reads mapped: 98.69

Strain: lineage4.8

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.24
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.32
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.31
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.34
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.69
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.67
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.71
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.62
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.47
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.47
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.45
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.47
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.53
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.47
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.38
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.35
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.36
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.33
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.25
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.31
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3086728 c.-92C>G upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246151 c.-363A>G upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0