TB-Profiler result

Run: ERR4821109
Summary

Run ID: ERR4821109

Sample name:

Date: 01-04-2023 17:04:05

Number of reads: 1104821

Percentage reads mapped: 88.28

Strain: lineage4.1.2.1

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 1.0
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.71 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 1.0
mshA 575679 p.Asn111Ser missense_variant 1.0
rpoB 759620 c.-187A>C upstream_gene_variant 0.2
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304855 p.Val642Asp missense_variant 0.5
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472498 n.653C>A non_coding_transcript_exon_variant 0.33
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.75
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.75
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.71
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.74
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.75
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.8
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.8
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.81
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.81
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.79
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.73
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.81
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.8
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.8
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.75
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.83
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.75
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.78
rrs 1472668 n.825_829delGGGTT non_coding_transcript_exon_variant 0.88
rrs 1472675 n.830_831insAGAC non_coding_transcript_exon_variant 0.83
rrs 1472680 n.835C>T non_coding_transcript_exon_variant 0.75
rrs 1472682 n.837T>C non_coding_transcript_exon_variant 0.78
rrs 1472683 n.838T>G non_coding_transcript_exon_variant 0.83
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.85
rrs 1472689 n.844C>T non_coding_transcript_exon_variant 0.68
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.73
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.82
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.79
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.72
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.76
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.76
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.5
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.5
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.47
rrs 1473278 n.1433T>C non_coding_transcript_exon_variant 0.25
rrl 1476359 n.2702C>T non_coding_transcript_exon_variant 0.2
rrl 1476443 n.2786G>C non_coding_transcript_exon_variant 0.2
rrl 1476455 n.2798C>G non_coding_transcript_exon_variant 0.2
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.29
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170349 p.Thr88Ala missense_variant 0.11
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embA 4243476 c.244C>T synonymous_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0