TB-Profiler result

Run: ERR4831719
Summary

Run ID: ERR4831719

Sample name:

Date: 01-04-2023 21:04:50

Number of reads: 574714

Percentage reads mapped: 93.22

Strain: lineage2.2.1

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.98
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.95
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761110 p.Asp435Val missense_variant 0.85 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 0.95 streptomycin
katG 2155129 p.Trp328Leu missense_variant 0.17 isoniazid
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2288971 p.Glu91* stop_gained 0.97 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5088 c.-152C>A upstream_gene_variant 0.14
gyrB 5809 c.570C>A synonymous_variant 0.13
gyrB 6350 c.1113delC frameshift_variant 0.13
gyrA 6904 c.-398C>G upstream_gene_variant 0.11
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7443 p.Leu48Ile missense_variant 0.13
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7777 p.Arg159Leu missense_variant 0.13
gyrA 7952 c.651C>A synonymous_variant 0.15
gyrA 8353 p.Gly351Val missense_variant 0.17
gyrA 8373 p.Leu358Met missense_variant 0.12
gyrA 8544 p.Asp415Tyr missense_variant 0.13
gyrA 8945 c.1644G>C synonymous_variant 0.11
gyrA 8946 c.1645T>C synonymous_variant 0.11
gyrA 8957 c.1656C>T synonymous_variant 0.13
gyrA 8967 p.Ala556Lys missense_variant 0.15
gyrA 8978 c.1677C>T synonymous_variant 0.15
gyrA 8987 c.1686C>G synonymous_variant 0.15
gyrA 8990 c.1689C>G synonymous_variant 0.12
gyrA 8993 c.1692C>T synonymous_variant 0.12
gyrA 8996 c.1695T>C synonymous_variant 0.12
gyrA 8998 p.Leu566Trp missense_variant 0.15
gyrA 9018 p.Gln573Asn missense_variant 0.17
gyrA 9023 c.1722A>C synonymous_variant 0.18
gyrA 9026 c.1725G>C synonymous_variant 0.17
gyrA 9029 c.1728T>C synonymous_variant 0.17
gyrA 9035 c.1734G>C synonymous_variant 0.25
gyrA 9044 c.1743C>G synonymous_variant 0.33
gyrA 9047 c.1746C>T synonymous_variant 0.33
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9482 c.2181G>T synonymous_variant 0.15
fgd1 490691 c.-92G>T upstream_gene_variant 0.25
fgd1 490721 c.-62C>A upstream_gene_variant 0.5
fgd1 491031 c.249C>T synonymous_variant 0.2
fgd1 491191 p.Gly137Arg missense_variant 0.17
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575401 c.54G>A synonymous_variant 0.22
mshA 575417 p.Ala24Thr missense_variant 0.29
mshA 575907 p.Ala187Val missense_variant 0.75
ccsA 620212 p.Gly108Cys missense_variant 0.25
ccsA 620493 c.603G>A synonymous_variant 0.17
ccsA 620625 p.Ile245Met missense_variant 1.0
ccsA 620758 p.Arg290Cys missense_variant 0.33
rpoB 759906 p.Ser34Pro missense_variant 0.11
rpoB 760522 p.Ser239Asn missense_variant 0.22
rpoB 760532 c.726T>C synonymous_variant 0.22
rpoB 760541 c.735G>C synonymous_variant 0.22
rpoB 760542 p.Phe246Leu missense_variant 0.22
rpoB 760581 p.Asp259His missense_variant 0.2
rpoB 760586 c.780C>T synonymous_variant 0.2
rpoB 760608 c.802C>T synonymous_variant 0.18
rpoB 760611 c.805T>C synonymous_variant 0.18
rpoB 760634 c.828T>C synonymous_variant 0.13
rpoB 760646 c.840C>G synonymous_variant 0.12
rpoB 760655 c.849A>G synonymous_variant 0.11
rpoB 761012 p.Asp402Glu missense_variant 0.4
rpoB 761139 p.His445* stop_gained 0.14
rpoB 761303 c.1497G>C synonymous_variant 0.15
rpoB 761318 c.1512G>T synonymous_variant 0.15
rpoB 761327 c.1521A>G synonymous_variant 0.13
rpoB 761333 c.1527G>T synonymous_variant 0.12
rpoB 761339 c.1533C>G synonymous_variant 0.12
rpoB 761352 p.Gly516Cys missense_variant 0.2
rpoB 761750 c.1944G>A synonymous_variant 0.4
rpoB 762044 c.2238C>T synonymous_variant 0.14
rpoB 762158 c.2352G>C synonymous_variant 0.17
rpoB 762167 c.2361T>C synonymous_variant 0.18
rpoB 762176 c.2370T>C synonymous_variant 0.18
rpoB 762185 c.2379G>C synonymous_variant 0.18
rpoB 762194 c.2388G>C synonymous_variant 0.22
rpoB 762233 c.2427G>C synonymous_variant 0.22
rpoB 762236 c.2430G>C synonymous_variant 0.22
rpoB 762455 p.His883Gln missense_variant 0.17
rpoB 762474 p.Gly890Cys missense_variant 0.25
rpoC 762995 c.-375G>T upstream_gene_variant 0.14
rpoC 763031 c.-339T>G upstream_gene_variant 0.94
rpoC 763034 c.-336C>G upstream_gene_variant 0.21
rpoC 763040 c.-330C>G upstream_gene_variant 0.21
rpoC 763070 c.-300T>C upstream_gene_variant 0.17
rpoC 763082 c.-288C>T upstream_gene_variant 0.18
rpoC 763088 c.-282C>G upstream_gene_variant 0.16
rpoC 763094 c.-276G>C upstream_gene_variant 0.12
rpoC 763525 p.Phe52Leu missense_variant 0.12
rpoC 763570 c.201G>C synonymous_variant 0.14
rpoC 763573 c.204G>C synonymous_variant 0.2
rpoC 763594 c.225C>T synonymous_variant 0.17
rpoC 763606 c.237C>G synonymous_variant 0.14
rpoC 763607 p.Val80Leu missense_variant 0.14
rpoC 763622 p.Ala85Ser missense_variant 0.14
rpoC 763627 p.Lys86Asn missense_variant 0.14
rpoC 763668 p.Pro100His missense_variant 0.13
rpoC 764687 p.Gln440Glu missense_variant 0.12
rpoC 764928 p.Lys520Arg missense_variant 0.12
rpoC 765102 p.Arg578Gln missense_variant 0.2
rpoC 765375 p.Gly669Val missense_variant 0.25
rpoC 765961 c.2592G>A synonymous_variant 0.18
rpoC 766239 p.Ile957Thr missense_variant 0.11
rpoC 767208 p.Ala1280Val missense_variant 0.15
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775834 p.Ala883Thr missense_variant 0.2
mmpL5 775999 p.Gly828Cys missense_variant 0.13
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 0.92
mmpL5 776863 p.His540Asn missense_variant 0.2
mmpL5 777996 p.Ala162Asp missense_variant 0.17
mmpS5 778665 p.Ile81Val missense_variant 0.18
mmpL5 779088 c.-608A>G upstream_gene_variant 0.2
mmpR5 779348 p.Val120Glu missense_variant 0.25
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781403 c.-157G>T upstream_gene_variant 0.14
rpsL 781446 c.-114G>A upstream_gene_variant 0.12
fbiC 1303114 p.Ala62Ser missense_variant 0.22
fbiC 1303605 c.675C>T synonymous_variant 0.25
fbiC 1303723 p.Glu265Lys missense_variant 0.12
fbiC 1304076 c.1146C>G synonymous_variant 0.2
fbiC 1304725 p.Val599Leu missense_variant 0.18
fbiC 1305322 p.Val798Met missense_variant 0.14
Rv1258c 1406311 p.Leu344Met missense_variant 0.12
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
Rv1258c 1407201 p.Val47Ala missense_variant 0.2
Rv1258c 1407336 p.Arg2Ile missense_variant 0.18
embR 1416327 p.Ile341Val missense_variant 0.12
embR 1416820 c.528C>A synonymous_variant 0.13
embR 1417453 c.-106G>A upstream_gene_variant 0.12
atpE 1461083 c.39T>A synonymous_variant 0.13
atpE 1461173 c.129C>A synonymous_variant 0.14
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472070 n.228_230delTGA non_coding_transcript_exon_variant 0.18
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.2
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.22
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.22
rrs 1472178 n.333C>A non_coding_transcript_exon_variant 0.22
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.2
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.2
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.18
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.18
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.17
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.19
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.28
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.28
rrs 1473028 n.1183A>T non_coding_transcript_exon_variant 0.13
rrl 1473403 n.-255C>A upstream_gene_variant 0.13
rrl 1473414 n.-244G>T upstream_gene_variant 0.14
rrl 1474476 n.819C>A non_coding_transcript_exon_variant 0.22
rrl 1474484 n.827C>A non_coding_transcript_exon_variant 0.33
rrl 1474869 n.1212G>T non_coding_transcript_exon_variant 0.29
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.22
inhA 1673700 c.-502C>T upstream_gene_variant 0.2
fabG1 1674139 p.Gly234Arg missense_variant 0.5
inhA 1674210 c.9A>C synonymous_variant 0.87
inhA 1674300 c.99C>A synonymous_variant 0.14
inhA 1674413 c.214delG frameshift_variant 0.22
inhA 1674855 c.654C>A synonymous_variant 0.5
rpsA 1833443 c.-99C>A upstream_gene_variant 0.18
rpsA 1833584 p.Asp15Asn missense_variant 0.15
rpsA 1834003 p.Glu154Asp missense_variant 0.22
rpsA 1834177 c.636A>C synonymous_variant 0.88
rpsA 1834309 c.768C>T synonymous_variant 0.18
rpsA 1834407 p.Arg289His missense_variant 0.33
tlyA 1917793 c.-147A>G upstream_gene_variant 0.22
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2101690 c.1353G>A synonymous_variant 0.5
ndh 2102162 p.Arg294Leu missense_variant 0.22
ndh 2102175 p.Ala290Ser missense_variant 0.22
ndh 2102413 c.630G>T synonymous_variant 0.18
ndh 2103081 c.-39A>G upstream_gene_variant 0.13
ndh 2103092 c.-50T>C upstream_gene_variant 0.15
ndh 2103158 c.-116C>T upstream_gene_variant 0.17
ndh 2103176 c.-134G>T upstream_gene_variant 0.2
ndh 2103234 c.-192G>A upstream_gene_variant 0.25
katG 2154099 c.2013G>A synonymous_variant 0.5
katG 2154421 p.Thr564Met missense_variant 0.25
katG 2154658 p.Gly485Asp missense_variant 0.25
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155308 c.804C>A synonymous_variant 0.17
katG 2155722 c.390G>T synonymous_variant 0.4
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2167931 c.2682C>A synonymous_variant 0.12
PPE35 2168108 c.2503_2504delAC frameshift_variant 0.14
PPE35 2168235 p.Ala793Glu missense_variant 0.5
PPE35 2168920 p.Val565Ile missense_variant 0.12
PPE35 2169091 p.Val508Leu missense_variant 0.14
PPE35 2170011 p.Arg201Leu missense_variant 0.4
PPE35 2170325 c.287delA frameshift_variant 0.29
PPE35 2170405 p.Ala70Thr missense_variant 0.25
PPE35 2170608 p.His2Pro missense_variant 0.12
Rv1979c 2222845 p.Gly107Val missense_variant 0.18
Rv1979c 2222863 p.Thr101Ile missense_variant 0.13
Rv1979c 2223287 c.-123G>A upstream_gene_variant 0.14
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289505 c.-264G>T upstream_gene_variant 0.12
pncA 2289784 c.-543C>A upstream_gene_variant 0.29
pncA 2289904 c.-663G>A upstream_gene_variant 0.12
kasA 2518182 p.Thr23Met missense_variant 0.25
kasA 2518239 p.Gly42Asp missense_variant 0.2
kasA 2518729 c.615G>A synonymous_variant 0.33
kasA 2519143 c.1029G>T synonymous_variant 0.29
kasA 2519168 p.Ala352Ser missense_variant 0.2
eis 2714334 c.999C>A synonymous_variant 0.2
eis 2714575 p.Trp253* stop_gained 0.2
eis 2715280 p.Leu18Pro missense_variant 0.17
ahpC 2726252 c.60C>A synonymous_variant 0.13
ahpC 2726260 p.Leu23Arg missense_variant 0.13
ahpC 2726338 p.Val49Gly missense_variant 0.24
folC 2747436 p.Asp55Tyr missense_variant 0.2
folC 2747590 c.9G>T synonymous_variant 0.29
pepQ 2860353 p.Met22Ile missense_variant 0.15
ribD 2987207 c.369C>T synonymous_variant 0.25
ribD 2987281 p.Val148Ala missense_variant 0.4
ribD 2987537 p.Gln233His missense_variant 0.29
Rv2752c 3064536 c.1656G>A synonymous_variant 0.15
Rv2752c 3064585 p.Thr536Lys missense_variant 0.18
Rv2752c 3064635 c.1557G>C synonymous_variant 0.11
Rv2752c 3065079 p.His371Gln missense_variant 0.5
Rv2752c 3065631 c.561C>A synonymous_variant 0.17
Rv2752c 3065918 p.Phe92Leu missense_variant 0.15
Rv2752c 3065929 p.Gly88Val missense_variant 0.2
Rv2752c 3067074 c.-883C>A upstream_gene_variant 0.18
thyX 3068035 c.-90G>T upstream_gene_variant 0.14
thyX 3068073 c.-128C>A upstream_gene_variant 0.12
thyA 3073932 p.Ser180Arg missense_variant 0.2
thyA 3074373 p.Gln33His missense_variant 0.17
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087083 c.264G>T synonymous_variant 0.29
ald 3087302 c.483C>T synonymous_variant 0.33
fbiD 3338952 c.-166C>A upstream_gene_variant 0.17
fbiD 3338963 c.-155C>A upstream_gene_variant 0.15
fbiD 3339161 p.Ala15Val missense_variant 0.29
fbiD 3339193 p.Leu26Met missense_variant 0.5
fbiD 3339243 p.Met42Ile missense_variant 0.22
fbiD 3339608 p.Pro164Arg missense_variant 0.4
fbiD 3339619 p.Ala168Ser missense_variant 0.38
Rv3083 3448367 c.-137G>T upstream_gene_variant 0.67
Rv3083 3448435 c.-69G>T upstream_gene_variant 0.15
Rv3083 3448508 p.Asn2Ser missense_variant 0.12
Rv3083 3448634 p.Thr44Asn missense_variant 0.22
Rv3083 3448660 p.Val53Leu missense_variant 0.33
Rv3083 3448723 p.Val74Leu missense_variant 0.13
Rv3083 3448955 p.Pro151Gln missense_variant 0.15
Rv3083 3448976 p.Arg158Pro missense_variant 0.22
Rv3083 3449442 c.939G>A synonymous_variant 0.14
Rv3083 3449718 c.1215C>T synonymous_variant 0.67
Rv3083 3449726 p.Arg408Gln missense_variant 0.67
Rv3083 3449792 p.Ala430Val missense_variant 0.22
fprA 3473852 c.-155G>T upstream_gene_variant 0.2
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474154 p.Arg50Cys missense_variant 0.2
fprA 3474887 p.Leu294Arg missense_variant 0.25
whiB7 3568433 p.Arg83Ser missense_variant 0.33
Rv3236c 3612286 c.830dupG frameshift_variant 0.15
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
fbiA 3640942 p.Asp134His missense_variant 0.15
fbiA 3641440 p.Gly300Trp missense_variant 0.2
fbiB 3641625 p.Ala31Thr missense_variant 0.8
fbiB 3641707 p.Gly58Val missense_variant 0.2
fbiB 3641727 p.Glu65* stop_gained 0.15
fbiB 3642272 c.738C>T synonymous_variant 0.4
fbiB 3642647 c.1113C>T synonymous_variant 0.29
fbiB 3642828 p.Pro432Ala missense_variant 0.25
alr 3840293 c.1128T>C synonymous_variant 0.1
alr 3840342 p.Gly360Asp missense_variant 0.12
alr 3840405 p.Gly339Ala missense_variant 0.25
alr 3841356 p.Ser22* stop_gained 0.15
alr 3841435 c.-15C>A upstream_gene_variant 0.16
rpoA 3877522 p.Thr329Asn missense_variant 0.17
rpoA 3877897 p.Pro204Gln missense_variant 0.5
rpoA 3877914 c.594C>T synonymous_variant 0.18
rpoA 3878263 p.Ser82Thr missense_variant 0.17
rpoA 3878417 p.Gly31Arg missense_variant 0.14
ddn 3986822 c.-22C>A upstream_gene_variant 0.12
ddn 3986964 p.Phe41Leu missense_variant 0.17
clpC1 4038526 p.Ile727Val missense_variant 0.13
clpC1 4038747 p.Arg653His missense_variant 0.25
clpC1 4039402 p.Lys435Glu missense_variant 0.12
clpC1 4039528 c.1177C>A synonymous_variant 0.12
clpC1 4039541 c.1164C>G synonymous_variant 0.12
clpC1 4039544 c.1161C>T synonymous_variant 0.14
clpC1 4039559 c.1146C>G synonymous_variant 0.22
clpC1 4039565 c.1140G>T synonymous_variant 0.22
clpC1 4039570 p.Met379Leu missense_variant 0.22
clpC1 4039571 c.1134G>A synonymous_variant 0.22
clpC1 4039574 p.Ala377Gly missense_variant 0.22
clpC1 4039586 c.1119G>C synonymous_variant 0.4
clpC1 4039601 c.1104G>A synonymous_variant 0.33
clpC1 4039610 c.1095G>C synonymous_variant 0.33
clpC1 4039616 c.1089G>C synonymous_variant 0.33
clpC1 4039619 c.1086G>A synonymous_variant 0.33
clpC1 4039622 c.1083C>T synonymous_variant 0.33
clpC1 4039649 c.1056G>C synonymous_variant 0.11
clpC1 4039661 c.1044T>C synonymous_variant 0.11
clpC1 4039739 c.966C>G synonymous_variant 0.12
clpC1 4039964 c.741C>G synonymous_variant 0.14
clpC1 4039975 p.Asp244Asn missense_variant 0.12
clpC1 4039979 c.726C>G synonymous_variant 0.13
clpC1 4039982 c.723G>A synonymous_variant 0.13
clpC1 4040015 c.690G>C synonymous_variant 0.12
clpC1 4040021 c.684A>T synonymous_variant 0.12
clpC1 4040024 c.681A>G synonymous_variant 0.13
clpC1 4040033 c.672G>C synonymous_variant 0.17
clpC1 4040048 c.657C>T synonymous_variant 0.29
clpC1 4040242 p.Thr155Ala missense_variant 0.18
clpC1 4040859 c.-155T>C upstream_gene_variant 0.18
embC 4239678 c.-185C>G upstream_gene_variant 0.33
embC 4239812 c.-51G>A upstream_gene_variant 0.15
embC 4240148 p.Gly96Arg missense_variant 0.2
embC 4240600 c.738G>A synonymous_variant 1.0
embC 4241086 c.1224G>A synonymous_variant 0.29
embC 4241424 p.Arg521Gln missense_variant 0.25
embC 4241879 p.Leu673Val missense_variant 0.1
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243290 p.Ser20Pro missense_variant 0.2
embA 4243460 c.228C>T synonymous_variant 1.0
embA 4243465 p.Ala78Asp missense_variant 0.4
embA 4243779 p.Pro183Ser missense_variant 0.29
embA 4244127 p.Thr299Ala missense_variant 0.2
embA 4244343 p.Ala371Ser missense_variant 0.33
embA 4245179 p.Met649Ile missense_variant 0.14
embA 4245182 c.1950T>C synonymous_variant 0.14
embA 4245354 p.Ala708Ser missense_variant 0.2
embA 4245393 p.Ala721Ser missense_variant 0.4
embA 4246446 p.Ala1072Thr missense_variant 0.25
embB 4246939 c.426C>A synonymous_variant 0.17
embB 4247154 p.Pro214Gln missense_variant 0.29
embB 4247331 p.Trp273Ser missense_variant 0.33
embB 4247353 p.Asp280Glu missense_variant 0.14
embB 4247916 c.1405delC frameshift_variant 0.25
embB 4247974 c.1461C>T synonymous_variant 0.25
embB 4247998 c.1485C>G synonymous_variant 0.12
embB 4248278 p.Pro589Thr missense_variant 0.15
embB 4248340 c.1827G>T synonymous_variant 0.17
embB 4248938 p.Pro809Ser missense_variant 0.29
embB 4249703 p.Leu1064Met missense_variant 0.25
embB 4249730 p.Ala1073Ser missense_variant 0.5
aftB 4267439 c.1398C>A synonymous_variant 0.29
aftB 4268266 p.Leu191Met missense_variant 0.5
aftB 4268708 c.129C>A synonymous_variant 0.22
aftB 4268900 c.-64C>A upstream_gene_variant 0.17
ubiA 4268951 p.Val295Phe missense_variant 0.25
ubiA 4269841 c.-8G>T upstream_gene_variant 0.29
ethA 4326712 p.Gln254His missense_variant 0.18
ethR 4327036 c.-513G>T upstream_gene_variant 0.14
ethR 4327444 c.-105C>A upstream_gene_variant 0.2
ethR 4327814 p.Thr89Asn missense_variant 0.15
ethR 4327951 p.Ala135Ser missense_variant 0.15
ethA 4328408 c.-935C>A upstream_gene_variant 0.29
whiB6 4338242 p.Gln94Lys missense_variant 0.2
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407833 p.Val124Met missense_variant 0.12
gid 4407927 p.Glu92Asp missense_variant 1.0
gid 4407956 p.Arg83Gly missense_variant 0.13
gid 4407980 p.Pro75Thr missense_variant 0.12
gid 4408124 p.Ala27Thr missense_variant 0.33