TB-Profiler result

Run: ERR4972477

Summary

Run ID: ERR4972477

Sample name:

Date: 01-04-2023 21:42:34

Number of reads: 135111

Percentage reads mapped: 84.53

Strain: lineage4.3.3

Drug-resistance: MDR-TB


Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3.3 Euro-American (LAM) LAM;T RD115 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
fabG1 1673425 c.-15C>T upstream_gene_variant 0.83 isoniazid, ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5711 p.Leu158Val missense_variant 0.5
gyrA 6592 c.-710C>A upstream_gene_variant 0.4
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7478 p.Met59Ile missense_variant 0.29
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7851 p.Gly184Ser missense_variant 0.5
gyrA 8040 p.Gly247Ser missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9380 p.Met693Ile missense_variant 0.33
rpoB 762856 p.Val1017Asp missense_variant 0.25
rpoC 764616 p.Asn416Ser missense_variant 1.0
rpoC 764797 c.1428G>T synonymous_variant 0.29
rpoC 764995 c.1626C>G synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777431 c.1047_1049delCGC disruptive_inframe_deletion 0.4
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303417 p.Gly163Cys missense_variant 0.5
embR 1417468 c.-121G>A upstream_gene_variant 0.5
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1473370 n.1525T>C non_coding_transcript_exon_variant 0.5
fabG1 1673388 c.-52T>A upstream_gene_variant 0.18
inhA 1674682 p.Met161Val missense_variant 1.0
rpsA 1834498 c.957C>T synonymous_variant 0.29
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154577 p.Gly512Ala missense_variant 0.5
katG 2156196 c.-85C>T upstream_gene_variant 1.0
PPE35 2170065 p.Ala183Gly missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518919 p.Gly269Ser missense_variant 1.0
kasA 2519128 c.1014G>C synonymous_variant 0.67
kasA 2519131 c.1017G>C synonymous_variant 0.67
kasA 2519140 c.1026G>C synonymous_variant 0.67
kasA 2519143 c.1029G>C synonymous_variant 0.67
eis 2714555 p.Asp260Tyr missense_variant 0.5
folC 2746340 p.Ala420Val missense_variant 1.0
folC 2746872 p.Glu243* stop_gained 0.5
thyX 3068090 c.-145T>C upstream_gene_variant 0.29
thyA 3073868 p.Thr202Ala missense_variant 1.0
Rv3083 3449736 c.1233G>A synonymous_variant 0.5
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
rpoA 3878339 p.Asp57Tyr missense_variant 0.2
clpC1 4038287 c.2418C>T synonymous_variant 1.0
clpC1 4038769 p.Arg646Gly missense_variant 0.25
panD 4044203 p.Thr27Ala missense_variant 0.29
embC 4240127 p.Gln89Glu missense_variant 0.4
embA 4242643 c.-590C>T upstream_gene_variant 1.0
aftB 4268619 p.Val73Gly missense_variant 1.0
whiB6 4338446 p.Leu26Met missense_variant 0.25
whiB6 4338587 c.-66T>C upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0