TB-Profiler result

Run: ERR6866540
Summary

Run ID: ERR6866540

Sample name:

Date: 02-04-2023 03:29:41

Number of reads: 2194246

Percentage reads mapped: 99.59

Strain: lineage4.1.1;lineage2.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.12
lineage4 Euro-American LAM;T;S;X;H None 0.86
lineage4.1 Euro-American T;X;H None 0.85
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.14
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.12
lineage4.1.1 Euro-American (X-type) X1;X2;X3 None 0.86
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6052 p.Ile271Met missense_variant 0.93
gyrB 7221 p.Ser661Thr missense_variant 0.88
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 0.16
mshA 575907 p.Ala187Val missense_variant 0.18
ccsA 620625 p.Ile245Met missense_variant 0.11
rpoC 765150 p.Gly594Glu missense_variant 0.88
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.12
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1416699 p.Leu217Val missense_variant 0.85
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rpsA 1834177 c.636A>C synonymous_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.12
PPE35 2167926 p.Leu896Ser missense_variant 0.16
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
Rv2752c 3067039 c.-848T>C upstream_gene_variant 0.11
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 0.91
embB 4249408 c.2895G>A synonymous_variant 0.91
aftB 4267647 p.Asp397Gly missense_variant 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.14
gid 4407927 p.Glu92Asp missense_variant 0.17