TB-Profiler result

Run: ERR702437
Summary

Run ID: ERR702437

Sample name:

Date: 02-04-2023 03:54:34

Number of reads: 4054583

Percentage reads mapped: 94.57

Strain: lineage4.6.4

Drug-resistance: HR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.6 Euro-American T;LAM None 1.0
lineage4.6.4 Euro-American T;LAM None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9121 p.Arg607His missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoC 766875 p.Asp1169Ala missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406666 p.Leu225Phe missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.5
rrs 1472210 n.365A>T non_coding_transcript_exon_variant 0.42
rrs 1472214 n.369C>G non_coding_transcript_exon_variant 0.36
rrs 1472235 n.390G>C non_coding_transcript_exon_variant 0.36
rrs 1472240 n.395G>C non_coding_transcript_exon_variant 0.38
rrs 1472242 n.397C>T non_coding_transcript_exon_variant 0.38
rrs 1472251 n.406G>T non_coding_transcript_exon_variant 0.2
rrs 1472252 n.407G>C non_coding_transcript_exon_variant 0.2
rrs 1472253 n.408G>T non_coding_transcript_exon_variant 0.2
rrs 1472256 n.411T>A non_coding_transcript_exon_variant 0.2
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.2
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.13
rrs 1472389 n.544G>A non_coding_transcript_exon_variant 0.2
rrs 1472390 n.545T>A non_coding_transcript_exon_variant 0.2
rrs 1472391 n.546C>T non_coding_transcript_exon_variant 0.2
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.2
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.13
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.35
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.45
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.47
rrs 1472785 n.940G>T non_coding_transcript_exon_variant 0.33
rrs 1472786 n.941C>G non_coding_transcript_exon_variant 0.33
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.12
rrs 1472814 n.969G>A non_coding_transcript_exon_variant 0.29
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.25
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.29
rrs 1472837 n.992C>T non_coding_transcript_exon_variant 0.18
rrs 1472993 n.1148G>A non_coding_transcript_exon_variant 0.15
rrs 1473038 n.1193A>C non_coding_transcript_exon_variant 0.2
rrs 1473044 n.1199C>G non_coding_transcript_exon_variant 0.21
rrs 1473053 n.1208T>A non_coding_transcript_exon_variant 0.22
rrs 1473068 n.1223A>G non_coding_transcript_exon_variant 0.21
rrs 1473070 n.1225G>C non_coding_transcript_exon_variant 0.19
rrs 1473071 n.1226C>A non_coding_transcript_exon_variant 0.2
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.25
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.25
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.16
rrs 1473094 n.1249T>C non_coding_transcript_exon_variant 0.16
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.16
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.15
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.15
rrl 1474454 n.797G>T non_coding_transcript_exon_variant 0.33
rrl 1474750 n.1093C>T non_coding_transcript_exon_variant 0.88
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.22
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.17
rrl 1476336 n.2679C>T non_coding_transcript_exon_variant 0.38
rrl 1476356 n.2699C>A non_coding_transcript_exon_variant 0.44
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.42
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.45
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.4
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.47
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.47
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.38
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.5
rrl 1476383 n.2726T>G non_coding_transcript_exon_variant 0.44
rrl 1476384 n.2727G>T non_coding_transcript_exon_variant 0.4
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.59
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.5
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.47
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.14
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.43
rrl 1476442 n.2785T>A non_coding_transcript_exon_variant 0.29
rrl 1476443 n.2786G>T non_coding_transcript_exon_variant 0.31
rrl 1476455 n.2798C>A non_coding_transcript_exon_variant 0.2
rrl 1476456 n.2799A>T non_coding_transcript_exon_variant 0.2
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.22
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.28
rrl 1476470 n.2813C>T non_coding_transcript_exon_variant 0.24
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.16
inhA 1674952 p.Pro251Ala missense_variant 0.17
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2155065 c.1047C>A synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289274 c.-33G>A upstream_gene_variant 1.0
eis 2714393 p.Val314Leu missense_variant 1.0
ahpC 2726443 p.Gly84Glu missense_variant 1.0
thyA 3073806 c.666C>G synonymous_variant 0.22
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
clpC1 4038857 c.1848C>A synonymous_variant 0.15
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4245324 p.Val698Ile missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0