TB-Profiler result

Run: ERR7363105
Summary

Run ID: ERR7363105

Sample name:

Date: 19-05-2023 14:35:11

Number of reads: 2957550

Percentage reads mapped: 99.65

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 9016 p.Thr572Asn missense_variant 0.99
gyrA 9648 p.Val783Leu missense_variant 0.99
mshA 576108 p.Ala254Gly missense_variant 0.17
mshA 576574 c.1227T>C synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 0.98
PPE35 2170065 p.Ala183Gly missense_variant 0.18
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289780 c.-539C>T upstream_gene_variant 1.0
ribD 2987581 p.Ser248Cys missense_variant 0.98
fbiD 3339734 p.Ala206Gly missense_variant 0.27
fbiD 3339744 c.627A>C synonymous_variant 0.15
Rv3083 3448497 c.-7T>A upstream_gene_variant 0.75
rpoA 3878675 c.-168A>T upstream_gene_variant 0.1
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243412 c.180C>T synonymous_variant 1.0
embB 4246584 p.Arg24Pro missense_variant 0.47
whiB6 4338596 c.-75G>A upstream_gene_variant 1.0
whiB6 4338597 c.-76A>G upstream_gene_variant 1.0
whiB6 4338598 c.-77G>C upstream_gene_variant 1.0
whiB6 4338599 c.-78A>C upstream_gene_variant 1.0