TB-Profiler result

Run: SRR13837502
Summary

Run ID: SRR13837502

Sample name:

Date: 03-04-2023 09:11:59

Number of reads: 595937

Percentage reads mapped: 96.34

Strain: lineage4.9

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
rpoB 760235 c.429T>C synonymous_variant 0.12
rpoB 760298 c.492G>C synonymous_variant 0.12
rpoB 760728 p.Tyr308Asn missense_variant 0.88
rpoB 760751 c.945G>C synonymous_variant 0.13
rpoB 760757 c.951T>C synonymous_variant 0.13
rpoB 760759 p.Val318Ala missense_variant 0.12
rpoB 760769 c.963C>G synonymous_variant 0.12
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.12
rpoB 760793 c.987A>G synonymous_variant 0.16
rpoB 760805 c.999G>C synonymous_variant 0.13
rpoB 760817 c.1011A>G synonymous_variant 0.17
rpoB 760820 c.1014T>C synonymous_variant 0.18
rpoB 760826 c.1020C>G synonymous_variant 0.15
rpoB 760830 c.1024T>C synonymous_variant 0.15
rpoB 760841 c.1035T>C synonymous_variant 0.19
rpoB 760845 p.Thr347Pro missense_variant 0.2
rpoB 760859 c.1053T>C synonymous_variant 0.14
rpoB 760862 c.1056G>C synonymous_variant 0.14
rpoB 760869 p.Val355Ile missense_variant 0.12
rpoB 760886 c.1080A>G synonymous_variant 0.12
rpoB 760925 c.1119T>C synonymous_variant 0.13
rpoB 760982 c.1176G>C synonymous_variant 0.12
rpoB 761057 c.1251G>C synonymous_variant 0.13
rpoB 761189 c.1383T>C synonymous_variant 0.16
rpoB 761195 c.1389G>C synonymous_variant 0.11
rpoB 761255 c.1449T>G synonymous_variant 0.12
rpoB 761261 c.1455G>T synonymous_variant 0.12
rpoB 761306 c.1500C>G synonymous_variant 0.12
rpoB 761327 c.1521A>G synonymous_variant 0.15
rpoB 761330 c.1524G>C synonymous_variant 0.14
rpoC 763928 p.Glu187* stop_gained 1.0
rpoC 764560 c.1191T>C synonymous_variant 0.11
rpoC 764566 c.1197C>G synonymous_variant 0.12
rpoC 764575 c.1206T>G synonymous_variant 0.12
rpoC 764593 c.1224C>T synonymous_variant 0.13
rpoC 764611 c.1242G>T synonymous_variant 0.17
rpoC 764650 c.1281G>C synonymous_variant 0.2
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.2
rpoC 766155 p.Ala929Val missense_variant 0.96
mmpL5 777185 c.1296G>T synonymous_variant 1.0
fbiC 1302932 p.Val1Gly missense_variant 1.0
fbiC 1303151 p.Gly74Asp missense_variant 1.0
fbiC 1304895 c.1965C>A synonymous_variant 1.0
fbiC 1305298 p.Lys790Gln missense_variant 1.0
Rv1258c 1406311 c.1030C>T synonymous_variant 1.0
rrl 1473416 n.-242G>C upstream_gene_variant 0.12
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.12
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.14
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.12
inhA 1674846 p.Ile215Met missense_variant 0.12
inhA 1674864 c.663C>T synonymous_variant 0.12
inhA 1674870 c.669T>C synonymous_variant 0.13
inhA 1674879 c.678T>C synonymous_variant 0.12
rpsA 1834275 p.Ile245Thr missense_variant 1.0
tlyA 1917936 c.-4C>A upstream_gene_variant 1.0
tlyA 1918315 p.Pro126Ala missense_variant 0.12
tlyA 1918330 p.Leu131Val missense_variant 0.12
ndh 2101676 p.Ala456Val missense_variant 1.0
katG 2155691 c.421T>C synonymous_variant 0.12
katG 2155695 c.417C>G synonymous_variant 0.12
katG 2155742 p.Gly124Arg missense_variant 0.11
katG 2155743 c.369G>C synonymous_variant 0.11
pncA 2289356 c.-115G>T upstream_gene_variant 1.0
kasA 2518234 p.Glu40Asp missense_variant 1.0
kasA 2519102 p.Gly330Arg missense_variant 0.15
Rv2752c 3064837 p.Leu452Trp missense_variant 1.0
thyX 3067869 p.Thr26Ser missense_variant 0.12
Rv3083 3449643 p.Asn380Lys missense_variant 1.0
fprA 3474752 p.Ile249Ser missense_variant 1.0
fprA 3475315 p.His437Asn missense_variant 1.0
Rv3236c 3611967 p.Ser384Pro missense_variant 1.0
rpoA 3877756 p.Ile251Thr missense_variant 1.0
rpoA 3878065 p.Pro148Arg missense_variant 1.0
ddn 3986977 p.Pro45Arg missense_variant 1.0
clpC1 4040538 p.Leu56Arg missense_variant 0.95
embC 4242791 p.Ala977Ser missense_variant 0.12
embA 4242796 c.-437G>C upstream_gene_variant 0.12
embA 4242799 c.-434T>C upstream_gene_variant 0.12
embA 4245342 p.Ser704Pro missense_variant 1.0
embB 4248711 c.2198_2199insT frameshift_variant 1.0
aftB 4267498 p.Glu447Lys missense_variant 1.0
aftB 4268559 p.Leu93Gln missense_variant 1.0