TB-Profiler result

Run: SRR13837631
Summary

Run ID: SRR13837631

Sample name:

Date: 2024-03-26T19:22:13.182261

Number of reads: 296607

Percentage reads mapped: 97.93

Median coverage: 10.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid ddn c.4_5insA Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
ddn 3986847 c.4_5insA frameshift_variant 1.0 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
fgd1 490804 p.Tyr8Asn missense_variant 1.0 clofazimine
pretomanid
delamanid
fgd1 490893 c.111C>T synonymous_variant 1.0 clofazimine
pretomanid
delamanid
mshA 575498 p.Ala51Pro missense_variant 1.0 ethionamide
isoniazid
rpoC 763663 c.294C>A synonymous_variant 0.88 rifampicin
rpoC 765682 p.Asn771Lys missense_variant 1.0 rifampicin
Rv1129c 1254119 p.Ser139Phe missense_variant 1.0 moxifloxacin
levofloxacin
rifampicin
isoniazid
embR 1416509 p.Arg280Pro missense_variant 1.0 ethambutol
rrl 1474164 n.507C>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
katG 2154959 c.1153C>A synonymous_variant 1.0 isoniazid
PPE35 2170236 c.376_377insG frameshift_variant 1.0 pyrazinamide Uncertain significance
pncA 2290061 c.-820C>T upstream_gene_variant 1.0 pyrazinamide
pepQ 2860252 p.Thr56Ser missense_variant 1.0 clofazimine
bedaquiline
Rv2680 2996652 p.Val183Ala missense_variant 1.0 capreomycin
rpoA 3877765 p.Ala248Gly missense_variant 1.0 rifampicin
embB 4247144 p.Ser211Pro missense_variant 1.0 ethambutol
ubiA 4269553 p.Ala94Gly missense_variant 1.0 ethambutol
gid 4408259 c.-57G>C upstream_gene_variant 1.0 streptomycin