TB-Profiler result

Run: SRR13837632
Summary

Run ID: SRR13837632

Sample name:

Date: 2024-10-05T14:21:10.006339

Number of reads: 293962

Percentage reads mapped: 99.06

Median coverage: 10.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
fgd1 490804 p.Tyr8Asn missense_variant 1.0 pretomanid
delamanid
clofazimine
mshA 575498 p.Ala51Pro missense_variant 1.0 isoniazid
ethionamide
rpoC 765682 p.Asn771Lys missense_variant 1.0 rifampicin
rpoC 766342 c.2973C>A synonymous_variant 1.0 rifampicin
rrl 1474164 n.507C>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
katG 2154959 c.1153C>A synonymous_variant 1.0 isoniazid
pncA 2290061 c.-820C>T upstream_gene_variant 1.0 pyrazinamide
folC 2747798 c.-200A>T upstream_gene_variant 1.0 para-aminosalicylic_acid
Rv2680 2996652 p.Val183Ala missense_variant 1.0 capreomycin
Rv2752c 3065651 p.Arg181Gly missense_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
mtrB 3626629 c.-17_-16insT upstream_gene_variant 1.0 rifampicin
bedaquiline
rpoA 3877765 p.Ala248Gly missense_variant 1.0 rifampicin
panD 4044948 c.-667A>G upstream_gene_variant 1.0 pyrazinamide
embB 4247059 c.546C>G synonymous_variant 1.0 ethambutol
embB 4247144 p.Ser211Pro missense_variant 1.0 ethambutol