TB-Profiler result

Run: SRR14802245

Summary

Run ID: SRR14802245

Sample name:

Date: 03-04-2023 12:21:44

Number of reads: 1060848

Percentage reads mapped: 99.65

Strain: lineage4.8

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 0.98
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5084 c.-156G>A upstream_gene_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 8824 p.Glu508Ala missense_variant 1.0
gyrA 9647 c.2346C>G synonymous_variant 0.25
mshA 576108 p.Ala254Gly missense_variant 0.14
mshA 576113 p.Arg256Gly missense_variant 0.43
mshA 576616 c.1269G>C synonymous_variant 0.5
rpoB 761482 p.Ala559Gly missense_variant 0.22
rpoC 764537 p.Pro390Ala missense_variant 0.14
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777883 p.Gly200Arg missense_variant 0.19
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
atpE 1461029 c.-16C>T upstream_gene_variant 0.96
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
fabG1 1673553 p.Asp38Glu missense_variant 0.3
fabG1 1673558 p.His40Pro missense_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519071 p.Asp319Glu missense_variant 0.23
pepQ 2860159 p.Ala87Gly missense_variant 0.25
Rv2752c 3064823 p.Val457Leu missense_variant 0.12
ald 3087816 p.Cys333Gly missense_variant 0.12
fbiD 3339734 p.Ala206Gly missense_variant 0.4
fprA 3474213 p.Lys69Asn missense_variant 0.11
whiB7 3568425 c.255T>G synonymous_variant 0.5
whiB7 3568431 c.249C>G synonymous_variant 0.27
alr 3840764 c.657G>C synonymous_variant 1.0
clpC1 4038853 p.Pro618Ala missense_variant 1.0
embC 4240409 p.Pro183Ala missense_variant 0.44
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246527 p.Ala5Gly missense_variant 0.22
embB 4247016 p.Ser168Trp missense_variant 0.26
embB 4247020 c.507C>G synonymous_variant 0.23
embB 4248328 c.1815G>C synonymous_variant 0.19
aftB 4268454 p.Val128Gly missense_variant 0.21
ethA 4328357 c.-884A>G upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0