TB-Profiler result

Run: SRR18213708
Summary

Run ID: SRR18213708

Sample name:

Date: 03-04-2023 19:26:08

Number of reads: 2889988

Percentage reads mapped: 99.61

Strain: lineage4.4.1.1

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.4 Euro-American S;T None 0.98
lineage4.4.1 Euro-American (S-type) S;T None 0.98
lineage4.4.1.1 Euro-American S;Orphans None 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761139 p.His445Asp missense_variant 1.0 rifampicin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 7085 p.Met616Val missense_variant 0.99
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 490751 c.-32T>G upstream_gene_variant 0.18
rpoB 759620 c.-187A>C upstream_gene_variant 0.14
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776687 p.Trp598Cys missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
inhA 1674952 p.Pro251Ala missense_variant 0.19
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2101892 p.Pro384Arg missense_variant 0.97
ndh 2102990 p.Val18Ala missense_variant 0.98
PPE35 2167984 p.Gly877Arg missense_variant 0.98
PPE35 2169840 p.Gly258Asp missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ahpC 2726338 p.Val49Gly missense_variant 0.33
thyA 3073806 c.666C>G synonymous_variant 0.27
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448608 c.105G>A synonymous_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612665 p.Val151Ala missense_variant 1.0
clpC1 4038857 c.1848C>A synonymous_variant 0.25
embA 4242586 c.-647C>T upstream_gene_variant 0.16
embA 4242643 c.-590C>T upstream_gene_variant 1.0
ethR 4327141 c.-408G>C upstream_gene_variant 0.98
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407973 p.Val77Ala missense_variant 0.99