TB-Profiler result

Run: SRR21277766
Summary

Run ID: SRR21277766

Sample name:

Date: 04-04-2023 01:39:38

Number of reads: 18244480

Percentage reads mapped: 97.35

Strain: lineage4.4.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.4 Euro-American S;T None 1.0
lineage4.4.2 Euro-American T1;T2 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 575888 p.Ala181Thr missense_variant 0.17
ccsA 619978 p.Leu30Met missense_variant 0.1
ccsA 620000 p.Ala37Asp missense_variant 0.13
mmpL5 775639 p.Ile948Val missense_variant 0.99
mmpL5 777310 p.Gly391Cys missense_variant 0.16
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303118 p.Ala63Glu missense_variant 0.15
fbiC 1304189 p.Pro420Gln missense_variant 0.25
fbiC 1305459 c.2529G>A synonymous_variant 0.1
fbiC 1305484 p.Ala852Thr missense_variant 0.11
Rv1258c 1407531 c.-191C>T upstream_gene_variant 0.18
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 0.93
tlyA 1918060 p.Lys41* stop_gained 0.13
tlyA 1918573 p.Ala212Thr missense_variant 0.12
tlyA 1918577 p.Arg213Gln missense_variant 0.12
tlyA 1918583 p.Ala215Glu missense_variant 0.14
tlyA 1918587 p.Gln216His missense_variant 0.18
katG 2155766 p.His116Asn missense_variant 0.17
katG 2155767 c.345C>A synonymous_variant 0.12
PPE35 2170357 p.Ala86Ser missense_variant 0.14
PPE35 2170434 p.Arg60Gln missense_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2715036 c.297G>T synonymous_variant 0.11
folC 2746323 p.Gly426* stop_gained 0.12
folC 2746340 p.Ala420Glu missense_variant 0.22
folC 2746620 c.979C>A synonymous_variant 0.15
pepQ 2859947 p.Val158Met missense_variant 0.1
pepQ 2860589 c.-171G>T upstream_gene_variant 0.29
Rv2752c 3066099 p.Met31Ile missense_variant 1.0
thyX 3067421 c.525G>A synonymous_variant 0.11
thyX 3067463 c.483C>A synonymous_variant 0.25
thyX 3067541 c.405C>A synonymous_variant 0.1
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339328 p.Ala71Thr missense_variant 0.14
fbiD 3339585 c.468C>A synonymous_variant 0.11
Rv3083 3448348 c.-156G>A upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3475308 c.1302C>A synonymous_variant 0.13
fbiB 3642002 p.Trp156Cys missense_variant 0.18
fbiB 3642039 p.Gly169Cys missense_variant 0.11
embC 4240403 p.Gly181Ser missense_variant 0.98
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244513 c.1281C>A synonymous_variant 0.18
embA 4244515 p.Ala428Glu missense_variant 0.29
embB 4246508 c.-6G>A upstream_gene_variant 1.0
embB 4247249 p.Gly246Arg missense_variant 1.0
embB 4247872 c.1359C>A synonymous_variant 0.17
aftB 4268928 c.-92C>T upstream_gene_variant 1.0
aftB 4269375 c.-539G>A upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0