TB-Profiler result

Run: SRR21700820
Summary

Run ID: SRR21700820

Sample name:

Date: 2025-03-05T11:55:35.469727

Number of reads: 7496321

Percentage reads mapped: 99.99

Median coverage: 230.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: HR-TB

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Trp505* Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2154598 p.Trp505* stop_gained 1.0 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
Rv1258c 1406686 p.Val219Ile missense_variant 1.0 isoniazid Uncertain significance
pyrazinamide Uncertain significance
streptomycin Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
PPE35 2170048 p.Leu189Val missense_variant 0.13 pyrazinamide Uncertain significance
embB 4246544 p.Thr11Pro missense_variant 0.26 ethambutol Uncertain significance
embB 4246548 p.Pro12Gln missense_variant 0.28 ethambutol Uncertain significance
embB 4246555 c.42G>C synonymous_variant 0.3 ethambutol Uncertain significance
embB 4246556 p.Ala15Pro missense_variant 0.29 ethambutol Uncertain significance
embB 4246563 p.Leu17Trp missense_variant 0.32 ethambutol Uncertain significance
embB 4246567 c.54G>T synonymous_variant 0.27 ethambutol Not assoc w R - Interim