TB-Profiler result

Run: SRR22536482
Summary

Run ID: SRR22536482

Sample name:

Date: 04-04-2023 04:19:32

Number of reads: 1326941

Percentage reads mapped: 99.65

Strain: lineage4.3.3

Drug-resistance: MDR-TB

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 0.99
lineage4.3.3 Euro-American (LAM) LAM;T RD115 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289090 p.His51Arg missense_variant 1.0 pyrazinamide
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8040 p.Gly247Ser missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 576111 p.Ala255Gly missense_variant 0.12
rpoC 764995 c.1626C>G synonymous_variant 1.0
rpoC 766487 p.Pro1040Thr missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303701 c.771C>T synonymous_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170018 p.Ala199Ser missense_variant 0.14
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518919 p.Gly269Ser missense_variant 1.0
Rv2752c 3065024 c.1167dupG frameshift_variant 0.4
Rv2752c 3065835 c.356delA frameshift_variant 0.61
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
whiB7 3568401 c.279G>T stop_lost&splice_region_variant 0.14
whiB7 3568428 c.252A>G synonymous_variant 0.16
rpoA 3878641 c.-135delG upstream_gene_variant 0.12
clpC1 4038287 c.2418C>T synonymous_variant 1.0
embC 4240441 p.Phe193Leu missense_variant 0.19
embC 4242182 p.Ala774Ser missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246553 c.40C>A synonymous_variant 0.27
embB 4246574 p.Ala21Ser missense_variant 0.3
embB 4247055 p.Leu181Gln missense_variant 0.2
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407754 p.Met150Arg missense_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0