TB-Profiler result

Run: SRR23861777
Summary

Run ID: SRR23861777

Sample name:

Date: 12-04-2023 03:34:18

Number of reads: 2849047

Percentage reads mapped: 99.65

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576093 p.Pro249Arg missense_variant 0.24
mshA 576100 p.Asp251Glu missense_variant 0.13
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
Rv2752c 3066031 p.Glu54Ala missense_variant 1.0
ald 3087095 c.276C>T synonymous_variant 1.0
whiB7 3568401 c.279G>T stop_lost&splice_region_variant 0.15
whiB7 3568416 p.Lys88His missense_variant 0.19
whiB7 3568428 c.252A>C synonymous_variant 0.34
whiB7 3568431 c.249C>G synonymous_variant 0.18
clpC1 4038186 p.Ala840Gly missense_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246552 p.Asn13Lys missense_variant 0.26
embB 4246559 p.Ile16Leu missense_variant 0.12
embB 4246569 p.Ala19Gly missense_variant 0.21
embB 4246574 p.Ala21Ser missense_variant 0.2
embB 4247013 p.Pro167Arg missense_variant 0.18
embB 4247016 p.Ser168Trp missense_variant 0.14
embB 4247023 c.510G>C synonymous_variant 0.14
embB 4247027 p.Leu172Gly missense_variant 0.14
ethA 4328004 c.-531C>A upstream_gene_variant 0.2
ethA 4328025 c.-552T>A upstream_gene_variant 0.18
ethR 4328030 p.Ala161Gly missense_variant 0.18
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0