TB-Profiler result

Run: SRR24466757

Summary

Run ID: SRR24466757

Sample name:

Date: 23-01-2024 07:10:46

Number of reads: 3134613

Percentage reads mapped: 99.56

Strain: lineage4

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 6463 c.-839C>T upstream_gene_variant 0.98
gyrA 7362 p.Glu21Gln missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 0.16
mshA 576651 p.Asp435Ala missense_variant 0.18
rpoC 765150 p.Gly594Glu missense_variant 0.14
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154980 c.1132C>T synonymous_variant 0.88
PPE35 2170811 c.-199C>T upstream_gene_variant 0.92
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2715352 c.-20A>C upstream_gene_variant 0.94
thyX 3067976 c.-31T>C upstream_gene_variant 0.88
Rv3083 3448385 c.-119C>G upstream_gene_variant 0.94
Rv3236c 3612290 p.Leu276Arg missense_variant 0.94
fbiB 3642615 p.Pro361Ala missense_variant 0.9
embA 4242643 c.-590C>T upstream_gene_variant 1.0
aftB 4268076 p.Met254Ala missense_variant 0.94
ethR 4326919 c.-630T>C upstream_gene_variant 0.92
whiB6 4338595 c.-75delG upstream_gene_variant 0.99
gid 4407938 p.Val89Leu missense_variant 0.93