TB-Profiler result

Run: SRR2467264
Summary

Run ID: SRR2467264

Sample name:

Date: 04-04-2023 04:44:27

Number of reads: 7262928

Percentage reads mapped: 99.48

Strain: lineage4.4.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.4 Euro-American S;T None 1.0
lineage4.4.2 Euro-American T1;T2 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491377 p.Gly199Arg missense_variant 1.0
rpoB 759620 c.-187A>C upstream_gene_variant 0.36
rpoC 762836 c.-534C>G upstream_gene_variant 0.3
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1475260 n.1608dupG non_coding_transcript_exon_variant 0.99
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.25
inhA 1674892 p.Asn231Asp missense_variant 0.29
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169866 c.747G>C synonymous_variant 0.54
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.33
Rv2752c 3064741 p.Gly484Ala missense_variant 0.44
Rv2752c 3066099 p.Met31Ile missense_variant 1.0
thyX 3067995 c.-50A>C upstream_gene_variant 0.2
thyA 3073806 c.666C>G synonymous_variant 0.21
thyA 3074654 c.-183T>G upstream_gene_variant 0.27
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339550 p.Gly145Trp missense_variant 0.19
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiB 3641955 p.Gly141Arg missense_variant 0.21
fbiB 3642734 c.1200G>C synonymous_variant 0.19
alr 3840268 p.Thr385Pro missense_variant 0.27
rpoA 3878238 p.Asp90Glu missense_variant 0.16
ddn 3987013 p.Gly57Ala missense_variant 0.19
ddn 3987175 p.Ala111Val missense_variant 1.0
clpC1 4038857 c.1848C>A synonymous_variant 0.16
clpC1 4039932 p.Gly258Val missense_variant 0.29
embC 4239842 c.-21C>A upstream_gene_variant 0.16
embC 4241456 p.Ala532Pro missense_variant 0.38
embA 4242643 c.-590C>T upstream_gene_variant 0.99
embC 4242822 p.Val987Gly missense_variant 0.34
embC 4242827 p.Leu989Val missense_variant 0.18
embB 4246508 c.-6G>A upstream_gene_variant 1.0
embB 4248725 p.Ser738Ala missense_variant 0.29
aftB 4268928 c.-92C>T upstream_gene_variant 1.0
aftB 4269375 c.-539G>A upstream_gene_variant 1.0
ubiA 4269529 p.Ala102Gly missense_variant 0.21
ethA 4327672 c.-199G>A upstream_gene_variant 0.2
whiB6 4338595 c.-75delG upstream_gene_variant 1.0