TB-Profiler result

Run: SRR4033782
Summary

Run ID: SRR4033782

Sample name:

Date: 04-04-2023 06:19:45

Number of reads: 636644

Percentage reads mapped: 99.49

Strain: lineage2.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.99
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8227 c.930_933delCGGT frameshift_variant 0.11
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoC 762539 c.-831G>A upstream_gene_variant 0.13
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 0.92
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rplC 801422 c.616dupG frameshift_variant 0.13
fbiC 1303782 c.852C>T synonymous_variant 0.12
fbiC 1305081 c.2151G>A synonymous_variant 0.13
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
embR 1416582 p.Arg256Cys missense_variant 0.33
embR 1416834 p.Leu172Val missense_variant 0.2
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472748 n.903C>A non_coding_transcript_exon_variant 0.11
rrl 1476332 n.2675G>T non_coding_transcript_exon_variant 0.12
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918197 c.258T>C synonymous_variant 0.2
ndh 2102888 p.Gln52Arg missense_variant 0.13
katG 2154477 c.1635G>A synonymous_variant 0.22
katG 2154568 p.Arg515His missense_variant 0.15
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155337 p.Asp259Asn missense_variant 0.18
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2169320 p.Leu431Phe missense_variant 0.29
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289845 c.-604G>A upstream_gene_variant 0.18
eis 2714716 p.Ala206Val missense_variant 0.15
ahpC 2726577 p.Gly129Cys missense_variant 0.18
Rv2752c 3064552 p.Arg547Pro missense_variant 0.2
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448417 c.-87C>G upstream_gene_variant 0.18
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
Rv3236c 3613018 c.99T>A synonymous_variant 0.13
fbiA 3641332 p.Gly264Arg missense_variant 1.0
alr 3841313 c.108C>T synonymous_variant 0.12
rpoA 3878059 p.Val150Ala missense_variant 0.15
rpoA 3878381 p.Leu43Met missense_variant 0.13
embC 4242075 p.Arg738Gln missense_variant 0.11
embC 4242425 p.Arg855Gly missense_variant 0.33
embC 4242615 p.Ala918Val missense_variant 0.33
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embA 4245174 p.Ser648Thr missense_variant 0.17
aftB 4267647 p.Asp397Gly missense_variant 1.0
ethA 4326017 p.Pro486Gln missense_variant 0.14
ethA 4326027 p.Arg483Gly missense_variant 0.12
ethA 4326056 p.Ile473Asn missense_variant 0.15
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0