TB-Profiler result

Run: SRR4034591
Summary

Run ID: SRR4034591

Sample name:

Date: 04-04-2023 06:54:27

Number of reads: 1176187

Percentage reads mapped: 99.78

Strain: lineage4.3.3

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 1.0
lineage4.3.3 Euro-American (LAM) LAM;T RD115 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8040 p.Gly247Ser missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
ccsA 620213 p.Gly108Asp missense_variant 0.11
rpoB 761446 p.Arg547His missense_variant 0.18
rpoC 763845 p.Arg159His missense_variant 0.14
rpoC 764995 c.1626C>G synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776780 p.Leu567Phe missense_variant 0.11
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1476056 n.2399G>A non_coding_transcript_exon_variant 1.0
rpsA 1834953 p.Ala471Val missense_variant 0.11
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2103146 c.-104G>A upstream_gene_variant 0.11
PPE35 2170198 p.Ala139Thr missense_variant 0.17
Rv1979c 2223051 p.Glu38Asp missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518919 p.Gly269Ser missense_variant 1.0
folC 2747459 c.139delC frameshift_variant 0.14
ribD 2987307 p.Ala157Pro missense_variant 0.25
Rv2752c 3064737 p.Gln485His missense_variant 0.11
Rv2752c 3065824 p.Pro123Leu missense_variant 1.0
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339323 p.Ala69Glu missense_variant 0.14
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3475268 p.Ala421Val missense_variant 0.13
fbiA 3641515 p.Asp325Tyr missense_variant 0.11
rpoA 3878582 c.-75C>A upstream_gene_variant 0.22
clpC1 4038287 c.2418C>T synonymous_variant 1.0
panD 4044176 p.Ala36Thr missense_variant 0.2
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4247114 p.Ala201Ser missense_variant 0.2
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0