TB-Profiler result

Run: SRR5485485
Summary

Run ID: SRR5485485

Sample name:

Date: 18-08-2022 08:28:46

Number of reads: 129811

Percentage reads mapped: 96.32

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761140 p.His445Pro missense_variant 0.94 rifampicin
rpoB 761142 p.Lys446Gln missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 1.0 kanamycin, capreomycin, aminoglycosides, amikacin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289253 c.-12T>C upstream_gene_variant 0.18 pyrazinamide
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6744 p.Val502Gly missense_variant 0.17
rpoB 761098 p.Ser431Asn missense_variant 1.0
rpoB 761138 c.1332C>G synonymous_variant 1.0
rpoB 761209 p.Asp468Gly missense_variant 0.17
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.23