TB-Profiler result

Run: SRR5485553

Summary

Run ID: SRR5485553

Sample name:

Date: 18-08-2022 08:26:40

Number of reads: 119571

Percentage reads mapped: 99.28

Strain:

Drug-resistance: MDR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761109 p.Asp435Tyr missense_variant 0.96 rifampicin
rpsL 781822 p.Lys88Arg missense_variant 1.0 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2288928 p.Gly105Asp missense_variant 1.0 pyrazinamide
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7601 c.300C>A synonymous_variant 0.14
gyrA 7664 p.Asn121Lys missense_variant 0.14
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.21
rrs 1473305 n.1460G>A non_coding_transcript_exon_variant 0.2