TB-Profiler result

Run: SRR5485561
Summary

Run ID: SRR5485561

Sample name:

Date: 18-08-2022 08:26:17

Number of reads: 154701

Percentage reads mapped: 99.3

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761139 p.His445Asn missense_variant 0.84 rifampicin
rpoB 761155 p.Ser450Trp missense_variant 0.16 rifampicin
fabG1 1673425 c.-15C>T upstream_gene_variant 1.0 isoniazid, ethionamide
katG 2155168 p.Ser315Thr missense_variant 0.15 isoniazid
pncA 2289114 p.His43Pro missense_variant 0.14 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7585 p.Ser95Thr missense_variant 0.9
gyrA 7625 c.324G>A synonymous_variant 0.15
rpoB 761228 p.Tyr474* stop_gained 0.17
rrs 1472302 n.457G>C non_coding_transcript_exon_variant 0.17
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.27
katG 2155097 p.Tyr339Asp missense_variant 0.14