TB-Profiler result

Run: SRR5485574
Summary

Run ID: SRR5485574

Sample name:

Date: 18-08-2022 08:25:08

Number of reads: 135590

Percentage reads mapped: 99.15

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
fabG1 1673425 c.-15C>T upstream_gene_variant 1.0 isoniazid, ethionamide
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289231 p.Leu4Trp missense_variant 1.0 pyrazinamide
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7662 p.Asn121Asp missense_variant 0.14
gyrA 7665 p.Asp122Asn missense_variant 0.14
rpoB 761226 p.Tyr474Glu missense_variant 0.17
rpsL 781661 p.Cys34Trp missense_variant 0.18
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.27
rrs 1473249 n.1404T>C non_coding_transcript_exon_variant 0.15
fabG1 1673412 c.-27G>A upstream_gene_variant 0.15
embB 4247616 p.Glu368Gly missense_variant 0.25