TB-Profiler result

Run: SRR5485593
Summary

Run ID: SRR5485593

Sample name:

Date: 18-08-2022 08:23:37

Number of reads: 88670

Percentage reads mapped: 99.21

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761109 p.Asp435Tyr missense_variant 0.92 rifampicin
katG 2155168 p.Ser315Thr missense_variant 0.3 isoniazid
pncA 2289015 p.Thr76Ile missense_variant 1.0 pyrazinamide
embB 4247429 p.Met306Leu missense_variant 0.93 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7585 p.Ser95Thr missense_variant 1.0
rpoB 761228 p.Tyr474* stop_gained 0.2
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.39
rrs 1472567 n.722G>A non_coding_transcript_exon_variant 0.2
katG 2155091 p.Trp341Gly missense_variant 0.18
pncA 2289047 c.195C>T synonymous_variant 1.0