TB-Profiler result

Run: SRR6046430
Summary

Run ID: SRR6046430

Sample name:

Date: 04-04-2023 12:16:34

Number of reads: 332578

Percentage reads mapped: 97.45

Strain:

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3.1.2 East-African-Indian CAS;CAS2 RD750 1.0
lineage3.1.2.2 East-African-Indian CAS RD750 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 6680 c.-622C>T upstream_gene_variant 0.13
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7629 p.Val110Met missense_variant 0.17
gyrA 8337 c.1036C>T synonymous_variant 0.12
gyrA 9091 p.Ala597Val missense_variant 0.15
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9611 c.2310C>T synonymous_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
ccsA 619831 c.-60T>G upstream_gene_variant 0.4
rpoB 759615 c.-192A>C upstream_gene_variant 0.38
rpoB 759746 c.-61C>T upstream_gene_variant 1.0
rpoB 761027 c.1221A>G synonymous_variant 0.18
rpoB 762031 p.Thr742Ile missense_variant 0.18
rpoC 762434 c.-936T>G upstream_gene_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 765751 c.2382C>T synonymous_variant 0.25
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.33
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.33
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.33
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.33
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.29
rrl 1475526 n.1869C>G non_coding_transcript_exon_variant 1.0
rpsA 1834434 p.Pro298Leu missense_variant 0.15
tlyA 1917881 c.-59C>T upstream_gene_variant 0.29
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167871 c.2742G>T synonymous_variant 0.17
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168591 c.2022G>A synonymous_variant 0.12
PPE35 2168604 p.Pro670Leu missense_variant 1.0
Rv1979c 2223097 p.Gly23Glu missense_variant 0.25
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 1.0
pncA 2289365 c.-125delC upstream_gene_variant 1.0
pncA 2289635 c.-394G>T upstream_gene_variant 0.22
kasA 2518147 c.33C>T synonymous_variant 0.29
ahpC 2726105 c.-88G>A upstream_gene_variant 0.96
Rv2752c 3065663 p.Pro177Thr missense_variant 0.18
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087476 c.657C>T synonymous_variant 1.0
fprA 3473982 c.-25C>T upstream_gene_variant 0.2
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiA 3640595 p.Gly18Val missense_variant 0.22
fbiB 3642474 p.Lys314Glu missense_variant 0.33
alr 3841506 c.-86A>C upstream_gene_variant 0.33
rpoA 3877879 p.Ser210Leu missense_variant 0.15
rpoA 3878044 p.Ser155Leu missense_variant 0.13
clpC1 4040155 p.Glu184Gln missense_variant 0.14
embC 4239679 c.-184T>C upstream_gene_variant 0.25
embC 4239973 c.111T>G synonymous_variant 0.2
embC 4242075 p.Arg738Gln missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
ethA 4326176 p.Glu433Ala missense_variant 1.0
ethR 4327598 p.Thr17Ile missense_variant 0.17
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4408238 c.-36A>T upstream_gene_variant 0.33