TB-Profiler result

Run: SRR6824479
Summary

Run ID: SRR6824479

Sample name:

Date: 04-04-2023 16:39:58

Number of reads: 10445256

Percentage reads mapped: 99.38

Strain: lineage4.5

Drug-resistance: MDR-TB

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.5 Euro-American H;T RD122 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
pncA 2289100 p.Lys48Glu missense_variant 0.59 pyrazinamide
ahpC 2726141 c.-52C>T upstream_gene_variant 1.0 isoniazid
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7892 c.591G>A synonymous_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 576612 p.Ala422Val missense_variant 1.0
ccsA 620029 c.139C>T synonymous_variant 1.0
rpoB 762427 p.Ser874Tyr missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303436 p.Ser169Phe missense_variant 0.99
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154181 p.Gly644Asp missense_variant 1.0
PPE35 2170568 p.Ile15Met missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
folC 2747195 p.Asp135Ala missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
rpoA 3878575 c.-68C>T upstream_gene_variant 1.0
clpC1 4038318 p.Pro796Leu missense_variant 1.0
clpC1 4040498 c.207G>A synonymous_variant 1.0
embC 4241584 p.Ile574Met missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243526 c.294G>A synonymous_variant 1.0
embA 4243760 p.Asp176Glu missense_variant 1.0
whiB6 4338594 c.-75delG upstream_gene_variant 1.0
gid 4408115 p.Gly30Arg missense_variant 1.0