TB-Profiler result

Run: SRR6824605
Summary

Run ID: SRR6824605

Sample name:

Date: 20-10-2023 19:28:24

Number of reads: 7399684

Percentage reads mapped: 99.58

Strain: lineage4.5;lineage4.4.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.5 Euro-American H;T RD122 0.29
lineage4.4 Euro-American S;T None 0.7
lineage4.4.2 Euro-American T1;T2 None 0.69
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6716 p.Ile493Leu missense_variant 0.25
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7892 c.591G>A synonymous_variant 0.29
gyrA 9304 p.Gly668Asp missense_variant 1.0
ccsA 620029 c.139C>T synonymous_variant 0.32
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471939 n.94C>T non_coding_transcript_exon_variant 0.61
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170568 p.Ile15Met missense_variant 0.26
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
Rv2752c 3065944 p.His83Pro missense_variant 0.72
Rv2752c 3066099 p.Met31Ile missense_variant 0.64
ald 3086788 c.-32T>C upstream_gene_variant 0.77
fbiD 3339480 p.Gln121His missense_variant 0.26
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474849 c.843G>A synonymous_variant 0.31
ddn 3987001 p.Gly53Asp missense_variant 0.34
clpC1 4038318 p.Pro796Leu missense_variant 0.3
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246508 c.-6G>A upstream_gene_variant 0.68
aftB 4268928 c.-92C>T upstream_gene_variant 0.72
aftB 4269375 c.-539G>A upstream_gene_variant 0.67
ethA 4327875 c.-402C>A upstream_gene_variant 0.21
whiB6 4338595 c.-75delG upstream_gene_variant 1.0