TB-Profiler result

Run: SRR6832157
Summary

Run ID: SRR6832157

Sample name:

Date: 04-04-2023 17:15:49

Number of reads: 633561

Percentage reads mapped: 99.56

Strain: lineage2.2.1

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575422 c.75C>T synonymous_variant 0.29
mshA 575583 p.Leu79Gln missense_variant 0.33
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoB 761575 p.Phe590Ser missense_variant 0.1
rpoB 762324 p.Lys840* stop_gained 0.13
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763700 p.Pro111Ser missense_variant 0.13
rpoC 766645 p.Glu1092Asp missense_variant 0.88
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpL5 776832 p.Thr550Ile missense_variant 0.18
mmpL5 778159 p.Phe108Val missense_variant 0.18
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781906 c.349delT frameshift_variant 0.15
fbiC 1304160 c.1230G>T synonymous_variant 0.25
fbiC 1305242 c.2315delT frameshift_variant 0.2
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
Rv1258c 1407372 c.-32C>T upstream_gene_variant 0.25
embR 1417170 p.Trp60Arg missense_variant 0.22
embR 1417171 c.176delT frameshift_variant 0.22
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1475060 n.1403A>C non_coding_transcript_exon_variant 0.18
rrl 1476659 n.3002A>G non_coding_transcript_exon_variant 0.2
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2519104 c.990T>C synonymous_variant 0.33
Rv2752c 3066074 p.Leu40Met missense_variant 0.33
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339330 c.213G>A synonymous_variant 0.33
fbiD 3339688 p.Thr191Pro missense_variant 0.18
Rv3083 3448795 p.Ile98Val missense_variant 0.2
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474743 p.Lys246Arg missense_variant 0.18
Rv3236c 3612301 c.816G>A synonymous_variant 0.5
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
rpoA 3878055 c.453A>G synonymous_variant 0.12
rpoA 3878215 p.Arg98His missense_variant 0.12
embC 4239858 c.-5G>A upstream_gene_variant 0.17
embC 4240774 c.912C>T synonymous_variant 0.25
embC 4241798 p.Phe646Leu missense_variant 0.17
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embB 4248071 p.Thr520Ala missense_variant 0.15
aftB 4267647 p.Asp397Gly missense_variant 1.0
ethA 4326342 p.Pro378Ser missense_variant 0.14
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338606 c.-85G>T upstream_gene_variant 0.15
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0