TB-Profiler result

Run: SRR6896163
Summary

Run ID: SRR6896163

Sample name:

Date: 04-04-2023 17:57:25

Number of reads: 374111

Percentage reads mapped: 99.17

Strain: lineage4.4.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.4 Euro-American S;T None 0.98
lineage4.4.2 Euro-American T1;T2 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 7239 p.Ala667Asp missense_variant 0.15
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 576031 c.686delG frameshift_variant 0.12
ccsA 620096 p.His69Pro missense_variant 0.67
rpoB 760539 p.Arg245Trp missense_variant 0.11
rpoC 766150 c.2781C>A synonymous_variant 0.12
rpoC 766691 p.Gly1108Cys missense_variant 0.14
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775857 p.Gly875Ala missense_variant 0.15
mmpL5 776153 p.Leu776Phe missense_variant 0.12
mmpL5 777642 p.Phe280Ser missense_variant 0.22
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304264 p.Gly445Val missense_variant 0.17
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472220 n.375G>T non_coding_transcript_exon_variant 0.18
rrl 1474487 n.830G>T non_coding_transcript_exon_variant 0.11
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102708 p.Tyr112Cys missense_variant 0.15
PPE35 2168757 p.Gln619Arg missense_variant 1.0
PPE35 2168780 p.His611Gln missense_variant 0.18
PPE35 2168961 p.Gly551Val missense_variant 0.13
PPE35 2170096 p.Arg173Trp missense_variant 0.14
PPE35 2170694 c.-82T>C upstream_gene_variant 0.22
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518151 p.Ser13Arg missense_variant 0.2
eis 2714615 p.Glu240Gln missense_variant 0.12
Rv2752c 3065625 c.567G>A synonymous_variant 0.15
Rv2752c 3066099 p.Met31Ile missense_variant 1.0
Rv2752c 3066322 c.-131G>T upstream_gene_variant 0.11
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448348 c.-156G>A upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiB 3642776 c.1242G>A synonymous_variant 0.33
alr 3840212 c.1209C>T synonymous_variant 1.0
clpC1 4038162 p.Arg848Leu missense_variant 0.17
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246031 c.-483G>A upstream_gene_variant 0.29
embB 4246508 c.-6G>A upstream_gene_variant 1.0
embB 4247249 p.Gly246Arg missense_variant 1.0
embB 4248246 p.Ile578Ser missense_variant 0.12
aftB 4268928 c.-92C>T upstream_gene_variant 1.0
aftB 4269375 c.-539G>A upstream_gene_variant 1.0
ubiA 4269712 p.Gly41Val missense_variant 0.12
whiB6 4338595 c.-75delG upstream_gene_variant 1.0