TB-Profiler result

Run: SRR6981944
Summary

Run ID: SRR6981944

Sample name:

Date: 04-04-2023 18:22:35

Number of reads: 509566

Percentage reads mapped: 99.64

Strain: lineage4.3.2.1

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 1.0
lineage4.3.2 Euro-American (LAM) LAM3 None 1.0
lineage4.3.2.1 Euro-American (LAM) LAM3 RD761 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5520 p.Pro94Leu missense_variant 1.0
gyrB 6431 p.Ala398Ser missense_variant 0.14
gyrA 7222 c.-80C>T upstream_gene_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9264 p.Asp655Tyr missense_variant 0.13
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoB 761792 c.1986T>C synonymous_variant 0.14
rpoC 764995 c.1626C>G synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 778431 p.Arg17Met missense_variant 0.18
mmpS5 778768 p.Asp46Glu missense_variant 0.1
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302870 c.-60delC upstream_gene_variant 0.11
Rv1258c 1406622 p.Leu240Pro missense_variant 0.11
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472337 n.492C>T non_coding_transcript_exon_variant 1.0
inhA 1673472 c.-730C>G upstream_gene_variant 0.12
inhA 1674596 p.Lys132Met missense_variant 0.2
rpsA 1833552 p.Pro4His missense_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102054 p.Pro330Gln missense_variant 0.13
ndh 2102170 c.873G>A synonymous_variant 0.1
PPE35 2168747 p.Ile622Met missense_variant 0.18
Rv1979c 2222034 c.1130delT frameshift_variant 0.12
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289717 c.-476A>G upstream_gene_variant 0.11
kasA 2518352 p.Met80Val missense_variant 0.11
kasA 2519361 p.Tyr416Phe missense_variant 0.11
folC 2746660 c.938delT frameshift_variant 0.13
Rv2752c 3065381 p.Arg271Cys missense_variant 0.13
Rv2752c 3065798 p.Gln132Lys missense_variant 0.12
thyA 3073868 p.Thr202Ala missense_variant 1.0
thyA 3074467 p.Thr2Met missense_variant 0.15
thyA 3074599 c.-128T>C upstream_gene_variant 0.11
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3086878 p.Pro20Gln missense_variant 0.18
fbiD 3339145 p.Ile10Phe missense_variant 0.12
Rv3083 3448518 c.15C>T synonymous_variant 0.15
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474101 p.Leu32Arg missense_variant 0.12
Rv3236c 3611992 c.1125T>C synonymous_variant 0.15
fbiA 3640407 c.-136G>A upstream_gene_variant 0.15
fbiB 3642117 p.Ala195Thr missense_variant 0.25
fbiB 3642877 p.Lys448Arg missense_variant 0.13
alr 3840282 c.1138delG frameshift_variant 0.1
clpC1 4038287 c.2418C>T synonymous_variant 1.0
panD 4044034 c.247delG frameshift_variant 0.12
embC 4240496 c.634C>T synonymous_variant 0.12
embC 4241648 c.1786T>C synonymous_variant 0.18
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244706 p.Thr492Ser missense_variant 0.18
embA 4245495 p.Gly755Ser missense_variant 0.14
embB 4245662 c.-852G>T upstream_gene_variant 0.15
aftB 4267560 p.Ala426Asp missense_variant 0.13
aftB 4267929 p.Arg303Leu missense_variant 0.29
ethR 4327853 p.Met102Thr missense_variant 0.12
whiB6 4338388 p.Pro45His missense_variant 0.13
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0
gid 4408405 c.-203G>A upstream_gene_variant 0.12