TB-Profiler result

Run: SRR8692879
Summary

Run ID: SRR8692879

Sample name:

Date: 13-08-2023 19:42:48

Number of reads: NA

Percentage reads mapped: NA

Strain: lineage4.9

Drug-resistance: HR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 0.99
lineage4.9 Euro-American (H37Rv-like) T1 None 0.99
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rplC 801268 p.Cys154Arg missense_variant 0.4 linezolid
katG 2154391 p.Ala574Glu missense_variant 0.13 isoniazid
katG 2155181 p.Asp311Tyr missense_variant 0.18 isoniazid
pncA 2289162 p.Leu27Pro missense_variant 0.18 pyrazinamide
embB 4247231 p.Asp240His missense_variant 0.22 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5926 c.687G>T synonymous_variant 0.22
gyrB 6912 p.Asn558Ile missense_variant 0.17
gyrB 7265 c.2026T>C stop_lost&splice_region_variant 0.12
gyrA 7397 c.96G>A synonymous_variant 0.2
gyrA 7571 c.270G>T synonymous_variant 0.17
gyrA 7694 c.393A>G synonymous_variant 0.11
gyrA 7710 c.409T>C synonymous_variant 0.12
gyrA 7715 c.414G>C synonymous_variant 0.13
gyrA 7728 c.427_429delAGGinsCGT synonymous_variant 0.15
gyrA 7874 c.573G>T synonymous_variant 0.25
gyrA 8550 p.Ala417Ser missense_variant 0.2
gyrA 8602 p.Ala434Val missense_variant 0.14
gyrA 9286 p.Ala662Glu missense_variant 0.14
gyrA 9375 p.Pro692Thr missense_variant 0.15
fgd1 491742 c.960T>C synonymous_variant 0.36
mshA 575690 p.Gly115Arg missense_variant 0.4
mshA 576200 p.Arg285Ser missense_variant 0.22
mshA 576247 c.900A>G synonymous_variant 0.4
mshA 576391 c.1044G>T synonymous_variant 0.4
mshA 576789 c.1442G>T stop_lost&splice_region_variant 0.2
rpoB 759989 c.183G>T synonymous_variant 0.15
rpoB 760643 p.Glu279Asp missense_variant 0.22
rpoB 760694 p.Lys296Asn missense_variant 0.18
rpoB 761165 c.1359G>C synonymous_variant 0.11
rpoB 761180 c.1374A>C synonymous_variant 0.12
rpoB 761189 c.1383T>C synonymous_variant 0.14
rpoB 761195 c.1389G>C synonymous_variant 0.14
rpoB 761198 c.1392G>T synonymous_variant 0.14
rpoB 761217 p.Pro471Ser missense_variant 0.2
rpoB 761220 c.1414_1416delTCGinsAGC synonymous_variant 0.2
rpoB 761261 c.1455G>C synonymous_variant 0.14
rpoB 761273 c.1467T>C synonymous_variant 0.14
rpoB 761408 c.1602G>T synonymous_variant 0.18
rpoB 761918 p.Asp704Glu missense_variant 0.14
rpoB 762114 p.Ile770Val missense_variant 0.22
rpoB 762122 c.2316C>T synonymous_variant 0.2
rpoB 762131 c.2325C>G synonymous_variant 0.17
rpoB 762137 c.2331C>T synonymous_variant 0.14
rpoB 762140 c.2334G>C synonymous_variant 0.14
rpoB 762143 c.2337T>C synonymous_variant 0.15
rpoB 762149 c.2343G>C synonymous_variant 0.15
rpoB 762156 p.Val784Ile missense_variant 0.15
rpoB 762167 c.2361T>C synonymous_variant 0.19
rpoB 762176 c.2370T>C synonymous_variant 0.18
rpoB 762185 c.2379G>C synonymous_variant 0.17
rpoB 762218 c.2412T>C synonymous_variant 0.22
rpoB 762233 c.2427G>C synonymous_variant 0.25
rpoB 762245 c.2439G>C synonymous_variant 0.24
rpoB 762284 c.2478G>C synonymous_variant 0.27
rpoB 762293 c.2487T>C synonymous_variant 0.27
rpoB 762296 c.2490G>C synonymous_variant 0.25
rpoB 762314 c.2508C>T synonymous_variant 0.25
rpoB 762317 c.2511A>G synonymous_variant 0.17
rpoB 762329 c.2523G>C synonymous_variant 0.14
rpoB 762347 c.2541T>C synonymous_variant 0.13
rpoB 762362 p.Glu852Asp missense_variant 0.13
rpoB 762369 c.2563T>C synonymous_variant 0.12
rpoC 762374 c.-996G>C upstream_gene_variant 0.12
rpoC 762380 c.-990T>C upstream_gene_variant 0.12
rpoC 763031 c.-339T>C upstream_gene_variant 0.17
rpoB 763106 p.Ile1100Met missense_variant 0.14
rpoC 763375 c.6C>A synonymous_variant 0.17
rpoC 763411 c.42T>C synonymous_variant 0.28
rpoC 763414 c.45T>G synonymous_variant 0.29
rpoC 763423 p.Glu18Asp missense_variant 0.31
rpoC 763430 c.61_63delAGGinsCGC synonymous_variant 0.29
rpoC 763433 p.Gln22Asn missense_variant 0.26
rpoC 763443 p.Tyr25Phe missense_variant 0.28
rpoC 763456 c.87A>G synonymous_variant 0.3
rpoC 763468 c.99G>C synonymous_variant 0.3
rpoC 763486 c.117T>C synonymous_variant 0.33
rpoC 763495 c.126G>A synonymous_variant 0.3
rpoC 763528 c.159G>A synonymous_variant 0.19
rpoC 763531 c.162G>T synonymous_variant 0.17
rpoC 763546 c.177A>G synonymous_variant 0.17
rpoC 763573 c.204G>C synonymous_variant 0.12
rpoC 763633 c.264T>C synonymous_variant 0.13
rpoC 764320 c.951C>T synonymous_variant 0.14
rpoC 764322 p.Pro318Gln missense_variant 0.14
rpoC 764329 c.960C>A synonymous_variant 0.15
rpoC 764353 c.984G>T synonymous_variant 0.18
rpoC 764365 c.996C>T synonymous_variant 0.25
rpoC 764371 c.1002G>C synonymous_variant 0.2
rpoC 764377 c.1008C>G synonymous_variant 0.2
rpoC 764380 c.1011G>C synonymous_variant 0.27
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.3
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.38
rpoC 764410 c.1041G>C synonymous_variant 0.44
rpoC 764431 c.1062G>C synonymous_variant 0.57
rpoC 764434 c.1065A>G synonymous_variant 0.67
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.67
rpoC 764452 c.1083T>C synonymous_variant 0.57
rpoC 764458 c.1089G>C synonymous_variant 0.4
rpoC 764461 c.1092A>G synonymous_variant 0.36
rpoC 764485 c.1116G>C synonymous_variant 0.36
rpoC 764491 c.1122G>T synonymous_variant 0.36
rpoC 764497 c.1128A>G synonymous_variant 0.33
rpoC 764500 c.1131C>G synonymous_variant 0.33
rpoC 764521 c.1152T>C synonymous_variant 0.2
rpoC 764527 c.1158C>T synonymous_variant 0.19
rpoC 764530 c.1161C>T synonymous_variant 0.13
rpoC 764539 c.1170C>G synonymous_variant 0.2
rpoC 764548 c.1179G>T synonymous_variant 0.18
rpoC 764575 c.1206T>G synonymous_variant 0.11
rpoC 764611 c.1242G>T synonymous_variant 0.16
rpoC 764626 c.1257C>T synonymous_variant 0.14
rpoC 764632 c.1263T>C synonymous_variant 0.14
rpoC 764650 c.1281G>T synonymous_variant 0.14
rpoC 764662 c.1293G>C synonymous_variant 0.15
rpoC 764665 c.1296C>A synonymous_variant 0.15
rpoC 764677 c.1308C>G synonymous_variant 0.16
rpoC 764746 c.1377G>T synonymous_variant 0.17
rpoC 764881 c.1512G>T synonymous_variant 0.33
rpoC 765119 p.Gly584Trp missense_variant 0.17
rpoC 765728 p.Gln787Lys missense_variant 0.18
rpoC 765800 p.Phe811Leu missense_variant 0.12
rpoC 765811 c.2442T>C synonymous_variant 0.12
rpoC 765814 c.2445A>C synonymous_variant 0.12
rpoC 765820 c.2451G>C synonymous_variant 0.12
rpoC 765823 c.2454C>G synonymous_variant 0.12
rpoC 765826 c.2457T>C synonymous_variant 0.12
rpoC 765861 p.Phe831Tyr missense_variant 0.17
rpoC 765875 p.Val836Ile missense_variant 0.15
rpoC 765892 c.2523T>C synonymous_variant 0.17
rpoC 765898 c.2529C>T synonymous_variant 0.15
rpoC 766036 c.2667C>T synonymous_variant 0.2
rpoC 766993 p.Met1208Ile missense_variant 0.15
rpoC 767098 c.3729T>C synonymous_variant 0.33
rpoC 767104 c.3735C>G synonymous_variant 0.33
rpoC 767106 p.Asn1246Met missense_variant 0.33
rpoC 767119 c.3750A>G synonymous_variant 0.43
rpoC 767155 c.3786C>G synonymous_variant 0.38
rpoC 767162 p.Asn1265Ala missense_variant 0.43
rpoC 767173 c.3804C>G synonymous_variant 0.5
rpoC 767174 p.Asn1269Asp missense_variant 0.5
rpoC 767180 p.Ala1271Gln missense_variant 0.5
rpoC 767185 c.3816G>C synonymous_variant 0.5
rpoC 767186 p.Gln1273Asn missense_variant 0.5
rpoC 767191 c.3822C>G synonymous_variant 0.43
rpoC 767197 c.3828G>A synonymous_variant 0.43
rpoC 767221 c.3852C>G synonymous_variant 0.5
rpoC 767230 c.3861G>C synonymous_variant 0.4
rpoC 767233 c.3864T>C synonymous_variant 0.33
mmpL5 775639 p.Ile948Val missense_variant 0.21
mmpL5 775684 p.Leu933Ile missense_variant 0.18
mmpL5 775851 p.Ser877Thr missense_variant 0.11
mmpL5 775862 c.2619G>C synonymous_variant 0.11
mmpL5 775916 c.2565T>C synonymous_variant 0.15
mmpL5 775955 p.Ile842Val missense_variant 0.16
mmpL5 775961 c.2520C>G synonymous_variant 0.17
mmpL5 775981 p.Leu834Met missense_variant 0.14
mmpL5 776798 c.1683G>T synonymous_variant 0.25
mmpL5 776876 p.Gln535His missense_variant 0.15
mmpL5 776900 p.Asn527Lys missense_variant 0.15
mmpL5 777417 p.Pro355Gln missense_variant 0.14
mmpL5 777434 c.1047C>A synonymous_variant 0.13
mmpL5 777533 c.948C>A synonymous_variant 0.18
mmpR5 778019 c.-971C>T upstream_gene_variant 0.13
mmpL5 778248 p.Ile78Thr missense_variant 0.13
mmpR5 779332 p.Gln115Lys missense_variant 0.25
mmpS5 779662 c.-757G>T upstream_gene_variant 0.14
rplC 800757 c.-52G>T upstream_gene_variant 0.33
rplC 800873 p.Arg22Lys missense_variant 0.13
rplC 801409 p.Arg201Ser missense_variant 0.14
fbiC 1304036 p.Arg369Leu missense_variant 0.18
fbiC 1304058 p.Glu376Asp missense_variant 0.15
fbiC 1304243 p.Pro438His missense_variant 0.29
fbiC 1304715 c.1785G>C synonymous_variant 0.13
fbiC 1304724 c.1794A>G synonymous_variant 0.14
fbiC 1304727 c.1797A>C synonymous_variant 0.14
fbiC 1304742 c.1812T>C synonymous_variant 0.12
fbiC 1304748 c.1818T>C synonymous_variant 0.12
fbiC 1304751 c.1821C>G synonymous_variant 0.13
fbiC 1304757 c.1827A>G synonymous_variant 0.12
fbiC 1304769 c.1839C>G synonymous_variant 0.11
fbiC 1304978 p.Gly683Val missense_variant 0.4
fbiC 1305208 p.Gly760Cys missense_variant 0.29
Rv1258c 1406414 c.927G>T synonymous_variant 0.14
Rv1258c 1406686 p.Val219Ile missense_variant 0.67
Rv1258c 1406727 p.Pro205Leu missense_variant 0.18
Rv1258c 1407342 c.-2T>C upstream_gene_variant 0.22
atpE 1461279 p.Pro79Thr missense_variant 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.25
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.25
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.29
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.25
rrs 1471979 n.134T>C non_coding_transcript_exon_variant 0.29
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.29
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.4
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.4
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.4
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.4
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.4
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.33
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.33
rrs 1472043 n.198T>G non_coding_transcript_exon_variant 0.33
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.4
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.4
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.29
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.29
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.5
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.42
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.42
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.5
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.55
rrs 1472502 n.657G>T non_coding_transcript_exon_variant 0.22
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.33
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.33
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.33
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.33
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.38
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.38
rrs 1472859 n.1014G>C non_coding_transcript_exon_variant 0.38
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.38
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.38
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.38
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.33
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.2
rrs 1473292 n.1447G>A non_coding_transcript_exon_variant 0.25
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.25
rrl 1473601 n.-57C>A upstream_gene_variant 0.15
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.18
rrl 1473814 n.157A>C non_coding_transcript_exon_variant 0.18
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.18
rrl 1473816 n.159C>G non_coding_transcript_exon_variant 0.18
rrl 1473828 n.171G>C non_coding_transcript_exon_variant 0.18
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.18
rrl 1473830 n.173T>G non_coding_transcript_exon_variant 0.18
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.18
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.2
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.2
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.2
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.2
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.2
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.2
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.33
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.36
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.44
rrl 1474452 n.795C>A non_coding_transcript_exon_variant 0.67
rrl 1474524 n.867C>A non_coding_transcript_exon_variant 0.33
rrl 1474775 n.1118G>T non_coding_transcript_exon_variant 0.4
rrl 1474810 n.1153G>T non_coding_transcript_exon_variant 0.29
rrl 1475235 n.1578C>A non_coding_transcript_exon_variant 0.15
rrl 1475255 n.1598C>A non_coding_transcript_exon_variant 0.15
rrl 1475343 n.1686A>G non_coding_transcript_exon_variant 0.38
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.5
rrl 1475358 n.1701T>C non_coding_transcript_exon_variant 0.5
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.5
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.56
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.56
rrl 1475381 n.1724G>T non_coding_transcript_exon_variant 0.56
rrl 1475382 n.1725A>C non_coding_transcript_exon_variant 0.56
rrl 1475395 n.1738T>G non_coding_transcript_exon_variant 0.62
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 0.62
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.62
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.62
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.56
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.5
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.33
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.33
rrl 1475562 n.1905C>A non_coding_transcript_exon_variant 0.18
rrl 1475640 n.1983G>T non_coding_transcript_exon_variant 0.25
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.62
rrl 1475759 n.2102C>T non_coding_transcript_exon_variant 0.62
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.62
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.56
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.56
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.5
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.55
rrl 1475860 n.2203C>A non_coding_transcript_exon_variant 0.17
rrl 1476189 n.2532C>A non_coding_transcript_exon_variant 0.17
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.25
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.25
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.29
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.4
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.44
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.44
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.5
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.55
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.55
rrl 1476476 n.2819G>T non_coding_transcript_exon_variant 0.33
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.57
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.27
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.2
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.22
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.2
inhA 1673454 c.-748C>A upstream_gene_variant 0.25
inhA 1674780 c.579T>G synonymous_variant 0.17
inhA 1674789 c.588G>C synonymous_variant 0.18
inhA 1674795 c.594G>C synonymous_variant 0.18
inhA 1674801 c.600T>C synonymous_variant 0.18
inhA 1674804 c.603G>C synonymous_variant 0.18
inhA 1674810 c.609C>G synonymous_variant 0.17
rpsA 1834012 c.471G>C synonymous_variant 0.13
rpsA 1834015 c.474G>C synonymous_variant 0.13
rpsA 1834030 c.489C>G synonymous_variant 0.12
rpsA 1834069 c.528G>C synonymous_variant 0.12
rpsA 1834167 p.Gly209Val missense_variant 0.17
rpsA 1834606 c.1065C>T synonymous_variant 0.12
rpsA 1834609 c.1068T>C synonymous_variant 0.12
rpsA 1834619 c.1078T>C synonymous_variant 0.15
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.15
rpsA 1834633 c.1092A>G synonymous_variant 0.12
rpsA 1834639 c.1098T>C synonymous_variant 0.12
rpsA 1834849 c.1308C>T synonymous_variant 0.18
tlyA 1917972 c.33A>G synonymous_variant 0.22
tlyA 1918660 p.Leu241Met missense_variant 0.22
ndh 2102281 c.762C>A synonymous_variant 0.2
ndh 2102563 c.480G>T synonymous_variant 0.14
ndh 2102611 c.432G>C synonymous_variant 0.12
katG 2154946 p.Ile389Thr missense_variant 0.17
katG 2156050 p.Pro21His missense_variant 0.18
katG 2156139 c.-28G>T upstream_gene_variant 0.14
katG 2156162 c.-51G>T upstream_gene_variant 0.15
katG 2156276 c.-165C>A upstream_gene_variant 0.15
PPE35 2167939 p.Ala892Thr missense_variant 0.22
PPE35 2167941 p.Ser891Thr missense_variant 0.22
PPE35 2168876 p.Phe579Leu missense_variant 0.2
PPE35 2168977 p.Ala546Ser missense_variant 0.17
Rv1979c 2222184 p.Trp327Cys missense_variant 0.18
Rv1979c 2222450 p.Ala239Ser missense_variant 0.13
Rv1979c 2222697 p.Asn156Lys missense_variant 0.18
Rv1979c 2222772 p.Glu131Asp missense_variant 0.13
Rv1979c 2222862 c.303C>A synonymous_variant 0.18
Rv1979c 2222899 p.Arg89Gln missense_variant 0.22
Rv1979c 2223078 c.87C>A synonymous_variant 0.29
pncA 2288854 p.Val130Leu missense_variant 0.33
pncA 2289527 c.-286C>G upstream_gene_variant 0.14
pncA 2290038 c.-797G>T upstream_gene_variant 0.17
eis 2714192 p.Gln381Lys missense_variant 0.17
eis 2714375 p.Val320Phe missense_variant 0.17
eis 2714653 p.Arg227Leu missense_variant 0.17
eis 2714660 p.Leu225Val missense_variant 0.17
eis 2714775 c.558G>T synonymous_variant 0.17
eis 2714785 p.Arg183Leu missense_variant 0.18
eis 2715187 p.Arg49His missense_variant 0.13
ahpC 2725968 c.-225C>A upstream_gene_variant 0.17
folC 2746276 p.Asp441Glu missense_variant 0.5
folC 2746879 p.Lys240Asn missense_variant 0.18
folC 2747628 c.-30G>T upstream_gene_variant 0.14
ribD 2986849 p.Ser4Tyr missense_variant 0.13
ribD 2987283 p.Ala149Ser missense_variant 0.22
ribD 2987614 c.776G>A splice_region_variant&stop_retained_variant 0.15
Rv2752c 3065202 c.990T>C synonymous_variant 0.11
Rv2752c 3065205 c.987T>C synonymous_variant 0.11
Rv2752c 3065223 c.969T>C synonymous_variant 0.11
Rv2752c 3065232 c.960T>C synonymous_variant 0.12
Rv2752c 3065241 c.951A>G synonymous_variant 0.11
Rv2752c 3067126 c.-935C>A upstream_gene_variant 0.13
thyX 3067824 p.Arg41Leu missense_variant 0.25
thyA 3074282 p.Arg64Ser missense_variant 0.13
thyA 3074298 p.Glu58Asp missense_variant 0.15
ald 3086788 c.-32T>C upstream_gene_variant 0.2
ald 3087874 p.Ser352Tyr missense_variant 0.18
ald 3087908 p.Phe363Leu missense_variant 0.2
fbiD 3339102 c.-16C>A upstream_gene_variant 0.29
fbiD 3339511 p.Ala132Ser missense_variant 0.22
Rv3083 3448357 c.-147C>A upstream_gene_variant 0.21
Rv3083 3449010 p.Trp169Cys missense_variant 0.15
fprA 3474099 p.Asp31Glu missense_variant 0.15
fprA 3474253 p.Val83Phe missense_variant 0.18
fprA 3474275 p.Pro90His missense_variant 0.17
fprA 3474278 p.Gly91Val missense_variant 0.17
fprA 3474301 p.Ala99Ser missense_variant 0.18
fprA 3475039 p.Gly345Cys missense_variant 0.22
fprA 3475342 p.Ser446Gly missense_variant 0.29
whiB7 3568419 c.261C>A synonymous_variant 0.17
Rv3236c 3612721 c.396G>T synonymous_variant 0.29
Rv3236c 3612863 p.Ser85Ile missense_variant 0.14
Rv3236c 3613153 c.-37G>T upstream_gene_variant 0.18
fbiA 3640405 c.-138G>T upstream_gene_variant 0.15
fbiA 3640419 c.-124G>T upstream_gene_variant 0.13
fbiB 3641960 c.426C>T synonymous_variant 0.2
fbiB 3641967 p.Ala145Ser missense_variant 0.18
alr 3840479 p.Tyr314* stop_gained 0.13
alr 3841073 c.348C>T synonymous_variant 0.17
alr 3841098 p.Pro108Leu missense_variant 0.18
alr 3841161 p.Ala87Asp missense_variant 0.22
alr 3841458 c.-38G>T upstream_gene_variant 0.15
alr 3841525 c.-105G>T upstream_gene_variant 0.15
alr 3841612 c.-192A>C upstream_gene_variant 0.17
rpoA 3877662 c.846C>T synonymous_variant 0.15
rpoA 3877665 c.843C>G synonymous_variant 0.15
rpoA 3877668 c.840A>G synonymous_variant 0.15
rpoA 3877674 c.834C>T synonymous_variant 0.15
rpoA 3877679 p.Ala277Ser missense_variant 0.15
rpoA 3877686 c.822A>G synonymous_variant 0.21
rpoA 3877692 c.816G>C synonymous_variant 0.25
rpoA 3877704 c.804G>T synonymous_variant 0.21
rpoA 3877728 c.780C>G synonymous_variant 0.21
rpoA 3877734 c.774G>C synonymous_variant 0.23
rpoA 3877737 c.771G>C synonymous_variant 0.25
rpoA 3877743 c.765T>C synonymous_variant 0.23
rpoA 3877749 c.759C>T synonymous_variant 0.25
rpoA 3877764 c.744C>G synonymous_variant 0.21
rpoA 3877770 c.738A>G synonymous_variant 0.2
rpoA 3877773 c.735G>C synonymous_variant 0.19
rpoA 3877776 c.732T>C synonymous_variant 0.13
rpoA 3877785 c.723C>G synonymous_variant 0.19
rpoA 3877803 c.705G>C synonymous_variant 0.14
rpoA 3877818 c.690A>G synonymous_variant 0.15
rpoA 3877964 c.544C>A synonymous_variant 0.17
rpoA 3878010 c.498C>A synonymous_variant 0.18
rpoA 3878360 p.Ala50Ser missense_variant 0.22
rpoA 3878572 c.-65G>T upstream_gene_variant 0.33
clpC1 4038607 p.Glu700* stop_gained 0.22
clpC1 4038640 p.Asp689Asn missense_variant 0.33
clpC1 4038647 c.2058T>C synonymous_variant 0.25
clpC1 4038650 c.2055C>T synonymous_variant 0.25
clpC1 4038658 p.Lys683Gln missense_variant 0.2
clpC1 4038661 p.Ser682Thr missense_variant 0.2
clpC1 4038662 c.2043T>C synonymous_variant 0.2
clpC1 4038671 c.2034T>G synonymous_variant 0.22
clpC1 4038677 p.Pro676Ala missense_variant 0.2
clpC1 4038683 c.2022T>C synonymous_variant 0.2
clpC1 4038704 c.2001T>C synonymous_variant 0.33
clpC1 4038707 c.1998C>G synonymous_variant 0.33
clpC1 4038710 c.1995G>C synonymous_variant 0.33
clpC1 4038713 c.1992T>C synonymous_variant 0.33
clpC1 4038755 c.1950G>C synonymous_variant 0.4
clpC1 4038773 c.1932T>C synonymous_variant 0.33
clpC1 4038779 c.1926C>G synonymous_variant 0.25
clpC1 4038782 c.1923G>C synonymous_variant 0.23
clpC1 4038790 c.1915C>T synonymous_variant 0.17
clpC1 4038795 p.Ser637Thr missense_variant 0.2
clpC1 4038812 c.1893T>C synonymous_variant 0.25
clpC1 4038815 c.1890G>T synonymous_variant 0.25
clpC1 4038830 c.1875C>T synonymous_variant 0.22
clpC1 4038836 c.1869G>C synonymous_variant 0.22
clpC1 4038852 p.Pro618Gln missense_variant 0.25
clpC1 4039064 c.1641C>T synonymous_variant 0.18
clpC1 4039067 c.1638G>C synonymous_variant 0.18
clpC1 4039079 c.1626C>G synonymous_variant 0.15
clpC1 4039085 c.1620A>G synonymous_variant 0.15
clpC1 4039091 c.1614G>C synonymous_variant 0.15
clpC1 4039097 c.1608G>C synonymous_variant 0.15
clpC1 4039112 c.1593C>G synonymous_variant 0.23
clpC1 4039118 c.1587C>G synonymous_variant 0.17
clpC1 4039121 c.1584T>C synonymous_variant 0.18
clpC1 4039142 c.1563A>G synonymous_variant 0.25
clpC1 4039145 c.1560G>C synonymous_variant 0.25
clpC1 4039169 p.Glu512Asp missense_variant 0.21
clpC1 4039183 c.1522T>C synonymous_variant 0.25
clpC1 4039187 c.1518G>C synonymous_variant 0.25
clpC1 4039208 c.1497C>G synonymous_variant 0.2
clpC1 4039226 c.1479T>C synonymous_variant 0.22
clpC1 4039517 c.1188C>A synonymous_variant 0.15
clpC1 4040015 c.690G>C synonymous_variant 0.12
clpC1 4040021 c.684A>C synonymous_variant 0.12
clpC1 4040024 c.681A>G synonymous_variant 0.12
clpC1 4040030 c.675C>G synonymous_variant 0.12
clpC1 4040033 c.672G>C synonymous_variant 0.13
clpC1 4040042 c.663C>T synonymous_variant 0.14
clpC1 4040057 c.648C>T synonymous_variant 0.14
clpC1 4040087 c.618G>C synonymous_variant 0.16
clpC1 4040090 c.615T>C synonymous_variant 0.11
clpC1 4040253 p.Ala151Asp missense_variant 0.18
clpC1 4040411 c.294T>C synonymous_variant 0.12
clpC1 4040426 c.279T>C synonymous_variant 0.11
clpC1 4040522 c.183T>C synonymous_variant 0.13
clpC1 4040531 c.174T>C synonymous_variant 0.14
clpC1 4040537 c.168G>C synonymous_variant 0.13
clpC1 4040671 p.Val12Phe missense_variant 0.17
panD 4043966 p.Val106Leu missense_variant 0.2
panD 4044230 p.Ala18Ser missense_variant 0.18
panD 4044377 c.-96G>T upstream_gene_variant 0.22
embC 4239900 p.Arg13Leu missense_variant 0.14
embC 4239906 p.Pro15Gln missense_variant 0.14
embC 4240007 p.Leu49Met missense_variant 0.22
embC 4240238 p.Ala126Ser missense_variant 0.17
embC 4240247 p.Asp129Tyr missense_variant 0.15
embC 4240289 p.Pro143Thr missense_variant 0.18
embC 4240625 p.Asp255Asn missense_variant 0.2
embC 4241235 p.Thr458Asn missense_variant 0.25
embC 4242094 p.Leu744Phe missense_variant 0.2
embC 4242239 p.Asp793Tyr missense_variant 0.18
embC 4242413 p.Leu851Met missense_variant 0.15
embC 4243079 p.Ala1073Thr missense_variant 0.25
embA 4244479 p.Thr416Lys missense_variant 0.15
embA 4244533 p.Thr434Asn missense_variant 0.13
embA 4244598 p.Leu456Met missense_variant 0.17
embA 4245500 p.Gln756His missense_variant 0.29
embA 4245525 p.Gly765Cys missense_variant 0.4
embB 4246753 c.240C>T synonymous_variant 0.25
embB 4246990 c.477C>A synonymous_variant 0.18
embB 4247013 p.Pro167Gln missense_variant 0.18
embB 4247226 p.Arg238His missense_variant 0.25
embB 4247362 c.849G>C synonymous_variant 0.29
embB 4247788 p.Tyr425* stop_gained 0.25
embB 4247815 c.1302C>A synonymous_variant 0.25
embB 4248130 c.1617G>T synonymous_variant 0.2
embB 4249124 p.Gly871Trp missense_variant 0.2
embB 4249241 c.2728C>T synonymous_variant 0.5
embB 4249766 p.Arg1085Cys missense_variant 0.14
aftB 4267168 p.Gln557Lys missense_variant 0.17
aftB 4267974 p.Ser288* stop_gained 0.17
aftB 4268604 p.Arg78Leu missense_variant 0.2
aftB 4268630 c.207G>T synonymous_variant 0.2
aftB 4269072 c.-236G>C upstream_gene_variant 0.12
aftB 4269084 c.-248G>C upstream_gene_variant 0.12
aftB 4269087 c.-251G>C upstream_gene_variant 0.11
aftB 4269123 c.-287T>G upstream_gene_variant 0.11
aftB 4269141 c.-307_-305delTTGinsCTC upstream_gene_variant 0.12
aftB 4269144 c.-308C>G upstream_gene_variant 0.12
ubiA 4269149 p.Val229Leu missense_variant 0.13
aftB 4269165 c.-329G>T upstream_gene_variant 0.17
aftB 4269171 c.-335C>G upstream_gene_variant 0.17
aftB 4269177 c.-341G>C upstream_gene_variant 0.25
ubiA 4269186 p.Thr216Ser missense_variant 0.25
ubiA 4269199 p.Ser212Asn missense_variant 0.27
aftB 4269201 c.-365A>G upstream_gene_variant 0.21
aftB 4269210 c.-374G>A upstream_gene_variant 0.15
ubiA 4269220 p.Ala205Lys missense_variant 0.17
aftB 4269222 c.-386T>C upstream_gene_variant 0.17
aftB 4269234 c.-398A>G upstream_gene_variant 0.18
ubiA 4269238 p.Ala199Val missense_variant 0.18
aftB 4269240 c.-404G>C upstream_gene_variant 0.18
ubiA 4269243 p.His197Gln missense_variant 0.18
aftB 4269249 c.-413G>A upstream_gene_variant 0.22
aftB 4269258 c.-422C>T upstream_gene_variant 0.17
aftB 4269264 c.-428C>T upstream_gene_variant 0.17
ubiA 4269271 p.Val188Ala missense_variant 0.17
aftB 4269291 c.-455A>G upstream_gene_variant 0.15
ubiA 4269297 p.Ile179Met missense_variant 0.14
ethR 4326880 c.-669G>T upstream_gene_variant 0.25
ethA 4327320 p.Gly52* stop_gained 0.13
ethA 4328208 c.-735G>T upstream_gene_variant 0.17
ethA 4328470 c.-997G>T upstream_gene_variant 0.27
whiB6 4338172 c.350G>T stop_lost&splice_region_variant 0.2
whiB6 4338184 p.Ala113Val missense_variant 0.2
whiB6 4338193 p.Arg110Leu missense_variant 0.22
whiB6 4338200 p.Asp108Tyr missense_variant 0.2
whiB6 4338259 p.Arg88Leu missense_variant 0.18
gid 4407625 p.Ala193Glu missense_variant 0.2
gid 4407634 p.Thr190Lys missense_variant 0.2