TB-Profiler result

Run: DRR014508
Summary

Run ID: DRR014508

Sample name:

Date: 31-03-2023 07:03:03

Number of reads: NA

Percentage reads mapped: NA

Strain: lineage4;lineage2.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.67
lineage4 Euro-American LAM;T;S;X;H None 0.28
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.67
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 0.67
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 0.96
gyrA 8147 p.Asn282Lys missense_variant 0.11
gyrA 9304 p.Gly668Asp missense_variant 0.96
fgd1 491742 c.960T>C synonymous_variant 0.74
mshA 575907 p.Ala187Val missense_variant 0.4
ccsA 620625 p.Ile245Met missense_variant 0.44
rpoC 763031 c.-339T>C upstream_gene_variant 0.74
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.76
mmpL5 776182 p.Asp767Asn missense_variant 0.34
mmpS5 779615 c.-710C>G upstream_gene_variant 0.67
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304501 p.Ala524Gly missense_variant 0.1
fbiC 1305357 c.2427C>G synonymous_variant 0.12
Rv1258c 1406760 c.580_581insC frameshift_variant 0.54
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1473893 n.236T>C non_coding_transcript_exon_variant 0.13
rpsA 1834177 c.636A>C synonymous_variant 0.67
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 0.75
PPE35 2167926 p.Leu896Ser missense_variant 0.72
PPE35 2168742 p.Gly624Asp missense_variant 0.11
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 0.75
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.94
Rv3236c 3612813 p.Thr102Ala missense_variant 0.67
fbiB 3640879 c.-656C>T upstream_gene_variant 0.13
rpoA 3878575 c.-68C>T upstream_gene_variant 0.13
rpoA 3878651 c.-144C>T upstream_gene_variant 0.1
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 0.68
aftB 4267647 p.Asp397Gly missense_variant 0.64
ethA 4326474 p.Pro334Ala missense_variant 0.14
ethA 4326676 p.Ser266Arg missense_variant 0.15
ethA 4327376 p.Ala33Gly missense_variant 0.11
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 0.72
gid 4407927 p.Glu92Asp missense_variant 0.65