TB-Profiler result

Run: ERR10680142
Summary

Run ID: ERR10680142

Sample name:

Date: 31-03-2023 10:38:21

Number of reads: 4799594

Percentage reads mapped: 99.57

Strain: lineage4.1

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761139 p.His445Tyr missense_variant 1.0 rifampicin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6507 p.Ala423Val missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9656 c.2355C>G synonymous_variant 1.0
mshA 576482 p.Val379Leu missense_variant 0.12
rpoC 765150 p.Gly594Glu missense_variant 1.0
rpoC 765187 c.1818C>T synonymous_variant 1.0
rpoC 766012 c.2643C>G synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775973 p.Leu836Phe missense_variant 1.0
mmpL5 776411 c.2070T>C synonymous_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781421 c.-139C>A upstream_gene_variant 1.0
fbiC 1303831 p.Thr301Ala missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2156007 c.105C>T synonymous_variant 1.0
PPE35 2170748 c.-136C>T upstream_gene_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518806 p.Asp231Ala missense_variant 1.0
pepQ 2860159 p.Ala87Gly missense_variant 0.15
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339734 p.Ala206Gly missense_variant 0.34
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
rpoA 3878588 c.-81G>A upstream_gene_variant 1.0
rpoA 3878613 c.-106A>C upstream_gene_variant 0.23
rpoA 3878618 c.-111A>C upstream_gene_variant 0.21
rpoA 3878641 c.-134C>G upstream_gene_variant 0.35
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embB 4246529 p.Ser6Arg missense_variant 0.26
embB 4246584 p.Arg24Pro missense_variant 0.3
embB 4248758 c.2245C>T synonymous_variant 1.0
whiB6 4338218 p.Asn102Asp missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408093 p.Gly37Glu missense_variant 1.0